Readers of PCNA modifications
| العنوان: | Readers of PCNA modifications |
|---|---|
| المؤلفون: | Helle D. Ulrich, Tomio S. Takahashi |
| المساهمون: | Biotechnologie et signalisation cellulaire (BSC), Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS)-Institut de recherche de l'Ecole de biotechnologie de Strasbourg (IREBS) |
| المصدر: | Chromosoma Chromosoma, Springer Verlag, 2013, 122 (4), pp.259-274. ⟨10.1007/s00412-013-0410-4⟩ |
| بيانات النشر: | Springer Nature |
| مصطلحات موضوعية: | SUMO protein, Review Article, DNA replication, DNA polymerase delta, RFC2, 03 medical and health sciences, 0302 clinical medicine, Replication factor C, Genome stability, Proliferating Cell Nuclear Antigen, Genetics, PCNA, Animals, Humans, [SDV.BBM]Life Sciences [q-bio]/Biochemistry, Molecular Biology, Genetics(clinical), Phosphorylation, Genetics (clinical), ComputingMilieux_MISCELLANEOUS, 030304 developmental biology, 0303 health sciences, DNA clamp, biology, Ubiquitin, Acetylation, Proliferating cell nuclear antigen, Chromatin, Cell biology, Posttranslational modifications, SUMO, biology.protein, Protein Processing, Post-Translational, 030217 neurology & neurosurgery, Protein Binding |
| الوصف: | The eukaryotic sliding clamp, proliferating cell nuclear antigen (PCNA), acts as a central coordinator of DNA transactions by providing a multivalent interaction surface for factors involved in DNA replication, repair, chromatin dynamics and cell cycle regulation. Posttranslational modifications (PTMs), such as mono- and polyubiquitylation, sumoylation, phosphorylation and acetylation, further expand the repertoire of PCNA’s binding partners. These modifications affect PCNA’s activity in the bypass of lesions during DNA replication, the regulation of alternative damage processing pathways such as homologous recombination and DNA interstrand cross-link repair, or impact on the stability of PCNA itself. In this review, we summarise our current knowledge about how the PTMs are “read” by downstream effector proteins that mediate the appropriate action. Given the variety of interaction partners responding to PCNA’s modified forms, the ensemble of PCNA modifications serves as an instructive model for the study of biological signalling through PTMs in general. Electronic supplementary material The online version of this article (doi:10.1007/s00412-013-0410-4) contains supplementary material, which is available to authorized users. |
| اللغة: | English |
| تدمد: | 0009-5915 1432-0886 |
| DOI: | 10.1007/s00412-013-0410-4 |
| DOI: | 10.1007/s00412-013-0410-4⟩ |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::637c176ee2aa369e41b5705b8a8b6800 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....637c176ee2aa369e41b5705b8a8b6800 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 00095915 14320886 |
|---|---|
| DOI: | 10.1007/s00412-013-0410-4 |