'Raising HOPE': Improved Outcomes for HIV/HCV-coinfected Liver Transplant Recipients in the Direct-acting Antiviral Era
| العنوان: | 'Raising HOPE': Improved Outcomes for HIV/HCV-coinfected Liver Transplant Recipients in the Direct-acting Antiviral Era |
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| المؤلفون: | John Fung, Amit G. Singal, Jorge A. Marrero, Sarah R. Lieber, Nicole E. Rich, Matthew A. Odenwald, Mack C. Mitchell, Jennifer Wang, Andrew Aronsohn, Thomas G. Cotter, Michael Charlton |
| المصدر: | Transplantation Direct, Vol 7, Iss 7, p e707 (2021) Transplantation Direct |
| بيانات النشر: | Ovid Technologies (Wolters Kluwer Health), 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | medicine.medical_specialty, RD1-811, Hepatitis C virus, medicine.medical_treatment, 030230 surgery, Liver transplantation, medicine.disease_cause, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, Medicine, Survival analysis, Transplantation, business.industry, Proportional hazards model, Hazard ratio, virus diseases, medicine.disease, Confidence interval, Liver Transplantation, Coinfection, Surgery, 030211 gastroenterology & hepatology, business |
| الوصف: | Background. The 2013 HIV Organ Policy Equity Act has increased liver transplantation (LT) in HIV+ patients; however, transplant centers may remain reluctant to perform LT in HIV/hepatitis C virus (HCV)-coinfected patients due to inferior outcomes. We aimed to assess how direct-acting antivirals (DAAs) have impacted HIV+/HCV+-coinfected LT recipient outcomes. Methods. national data including 70 125 adult LT recipients between 2008 and 2019 were analyzed. Kaplan-Meier survival analysis and Cox proportional hazards model were used to analyze outcomes. Results. LT for HIV+ individuals increased in the DAA era from 28 in 2014 to 64 in 2019 (23 had HIV+/HCV+ coinfection). In the pre-DAA era, HIV+/HCV+-coinfected LT recipients had an increased risk of graft failure compared with HIV−/HCV−-uninfected LT recipients (hazard ratio [HR], 1.85; P |
| تدمد: | 2373-8731 |
| DOI: | 10.1097/txd.0000000000001154 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63727f8c6129f2e26da9fc81de75213b https://doi.org/10.1097/txd.0000000000001154 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....63727f8c6129f2e26da9fc81de75213b |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 23738731 |
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| DOI: | 10.1097/txd.0000000000001154 |