التفاصيل البيبلوغرافية
العنوان:
Pyridazine and pyridazinone derivatives as potent and selective factor XIa inhibitors
المؤلفون:
Wei Han , Ruth R. Wexler , Yiming Wu , Cailan Wang , Joseph M. Luettgen , Zilun Hu , Karen A. Rossi , Jeffrey M. Bozarth , Steven Sheriff , Joseph E. Myers , Dietmar A. Seiffert , Mimi L. Quan
المصدر:
Bioorganicmedicinal chemistry letters . 28(6)
سنة النشر:
2018
مصطلحات موضوعية:
0301 basic medicine , Models, Molecular , Serine Proteinase Inhibitors , Clinical Biochemistry , Pharmaceutical Science , Factor XIa , Pharmacology , Crystallography, X-Ray , 01 natural sciences , Biochemistry , Pyridazine , 03 medical and health sciences , chemistry.chemical_compound , Structure-Activity Relationship , Drug Discovery , Humans , Molecular Biology , Dose-Response Relationship, Drug , Molecular Structure , 010405 organic chemistry , Chemistry , Organic Chemistry , 0104 chemical sciences , Bioavailability , Pyridazines , 030104 developmental biology , Coagulation factor XIa , Microsomes, Liver , Molecular Medicine
الوصف:
Pyridazine and pyridazinone derivatives were designed and synthesized as coagulation factor XIa inhibitors. Potent and selective inhibitors with single digit nanomolar affinity for factor XIa were discovered. Selected inhibitors demonstrated moderate oral bioavailability.
تدمد:
1464-3405
URL الوصول:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::634978adce71914a42a7f5d8e2dbc094 https://pubmed.ncbi.nlm.nih.gov/29501396
Rights:
CLOSED
رقم الانضمام:
edsair.doi.dedup.....634978adce71914a42a7f5d8e2dbc094
قاعدة البيانات:
OpenAIRE