Introduction of Re(CO)3+/99mTc(CO)3+ Organometallic Species into Vinylpyrrolidone-Allyliminodiacetate Copolymers
| العنوان: | Introduction of Re(CO)3+/99mTc(CO)3+ Organometallic Species into Vinylpyrrolidone-Allyliminodiacetate Copolymers |
|---|---|
| المؤلفون: | Olga V. Nazarova, Andrei Yur'evich Murko, E. F. Panarin, Sergei Vasilievich Shatik, Valerii D. Krasikov, N. I. Gorshkov, Yulia Zolotova |
| المصدر: | Polymers Volume 13 Issue 11 Polymers, Vol 13, Iss 1832, p 1832 (2021) |
| بيانات النشر: | MDPI AG, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Polymers and Plastics, Metal ions in aqueous solution, Organic chemistry, Infrared spectroscopy, rhenium, 02 engineering and technology, Article, 03 medical and health sciences, chemistry.chemical_compound, QD241-441, 0302 clinical medicine, Blood serum, Moiety, Chelation, Methylene, iminodiacetate chelator, carbonyl, General Chemistry, 021001 nanoscience & nanotechnology, chemistry, Polymerization, 030220 oncology & carcinogenesis, Proton NMR, technetium-99m, 0210 nano-technology, vinylpyrrolidone-allylamine copolymers, Nuclear chemistry |
| الوصف: | N-vinylpyrrolidone-co-allylamine copolymers (VP-co-AA) containing iminodiacetic (IDA) chelation units were prepared in the range of molecular masses of the copolymers from 9000 to 30,000 Da depending on polymerization conditions. Non-radioactive organometallic species Re(CO)3+ were introduced into polymeric carriers under mild conditions the prepared metal–polymeric complexes were characterized by IR, NMR, ESI-MS and HPLC. IR spectra data confirmed the coordination of M(CO)3+ moiety to the polymeric backbone via IDA chelation unit (appearance of characteristic fac-M(CO)3+ vibrations (2005, 1890 cm−1), as well as the appearance of group of signals in 1H NMR spectra, corresponding to those inequivalent to methylene protons CH2COO (dd, 4.2 ppm), coordinated to metal ions. The optimal conditions for labeling the PVP-co-AA-IDA copolymers with radioactive 99mTc(CO)3+ species were determined. The radiochemical yields reached 97%. The obtained radiolabeled polymers were stable in blood serum for 3 h. In vivo distribution experiments in intact animals showed the high primary accumulation of technetium-99m MPC (MM = 15,000 Da) in blood with subsequent excretion via the urinary tract. |
| وصف الملف: | application/pdf |
| تدمد: | 2073-4360 |
| DOI: | 10.3390/polym13111832 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::631fe1ac34bf63d8f6e595d49fe371f9 https://doi.org/10.3390/polym13111832 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....631fe1ac34bf63d8f6e595d49fe371f9 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20734360 |
|---|---|
| DOI: | 10.3390/polym13111832 |