Treatment With Recombinant Placental Growth Factor (PlGF) Enhances Both Angiogenesis and Arteriogenesis and Improves Survival After Myocardial Infarction
| العنوان: | Treatment With Recombinant Placental Growth Factor (PlGF) Enhances Both Angiogenesis and Arteriogenesis and Improves Survival After Myocardial Infarction |
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| المؤلفون: | Satoshi Somekawa, Tamio Nakajima, Kenichi Ishigami, Minoru Takaoka, Yoshihiko Saito, Yasuhiro Takemoto, Keiichi Imagawa, Kenji Onoue, Tsunenari Soeda, Manabu Horii, Shiro Uemura, Yukiji Takeda, Hajime Iwama, Taku Nishida, Hiroyuki Kawata, Satoshi Okayama, Atsushi Kubo |
| المصدر: | Circulation Journal. 73:1674-1682 |
| بيانات النشر: | Japanese Circulation Society, 2009. |
| سنة النشر: | 2009 |
| مصطلحات موضوعية: | Placental growth factor, Time Factors, Angiogenesis, Myocardial Infarction, Pregnancy Proteins, Ventricular Function, Left, Neovascularization, Mice, chemistry.chemical_compound, Cell Movement, Antigens, Ly, Myocardial infarction, Ventricular Remodeling, Stem Cells, Cell Differentiation, Infusion Pumps, Implantable, General Medicine, Coronary Vessels, Recombinant Proteins, Platelet Endothelial Cell Adhesion Molecule-1, Vascular endothelial growth factor, medicine.anatomical_structure, Cardiology, medicine.symptom, Cardiology and Cardiovascular Medicine, medicine.medical_specialty, Green Fluorescent Proteins, Neovascularization, Physiologic, Mice, Transgenic, Internal medicine, medicine, Animals, Humans, Progenitor cell, Placenta Growth Factor, Vascular Endothelial Growth Factor Receptor-1, business.industry, Endothelial Cells, Membrane Proteins, medicine.disease, Vascular Endothelial Growth Factor Receptor-2, Actins, Mice, Inbred C57BL, Disease Models, Animal, chemistry, Cancer research, Angiogenesis Inducing Agents, Arteriogenesis, Bone marrow, business |
| الوصف: | Background Placental growth factor (PlGF), a homolog of vascular endothelial growth factor, is reported to stimulate angiogenesis and arteriogenesis in pathological conditions. It was recently demonstrated that PlGF is rapidly produced in myocardial tissue during acute myocardial infarction (MI). However, the effects of exogenous PlGF administration on the healing process after MI are not fully understood. The purpose of the present study was to examine whether PlGF treatment has therapeutic potential in MI. Methods and results Recombinant human PlGF (rhPlGF: 10 microg) was administered continuously for 3 days in a mouse model of acute MI. rhPlGF treatment significantly improved survival rate after MI and preserved cardiac function relative to control mice. The numbers of CD31-positive cells and alpha-smooth muscle actin-positive vessels in the infarct area were significantly increased in the rhPlGF group. Endothelial progenitor cells (Flk-1(+)Sca-1(+) cells) were mobilized by rhPlGF into the peripheral circulation. Furthermore, rhPlGF promoted the recruitment of GFP-labeled bone marrow cells to the infarct area, but only a few of those migrating cells differentiated into endothelial cells. Conclusions Exogenous PlGF plays an important role in healing processes by improving cardiac function and stimulating angiogenesis following MI. It can be considered as a new therapeutic molecule. |
| تدمد: | 1347-4820 1346-9843 |
| DOI: | 10.1253/circj.cj-08-1067 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62d1c8824a2cc777cf9e3c93f18987b6 https://doi.org/10.1253/circj.cj-08-1067 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....62d1c8824a2cc777cf9e3c93f18987b6 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 13474820 13469843 |
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| DOI: | 10.1253/circj.cj-08-1067 |