Drug hypersensitivity in children: a retrospective analysis of 101 pharmacovigilance reports
| العنوان: | Drug hypersensitivity in children: a retrospective analysis of 101 pharmacovigilance reports |
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| المؤلفون: | Maria Katsogiannou, Julie Mazenq, Jean-Christophe Dubus, Marie-José Gervoise-Boyer, Ania Carsin |
| المساهمون: | Hôpital de la Timone [CHU - APHM] (TIMONE), Service de pédiatrie multidisciplinaire [Hôpital de la Timone Enfants - APHM], Microbes évolution phylogénie et infections (MEPHI), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS) |
| المصدر: | European journal of pediatrics European journal of pediatrics, 2021, 180 (2), pp.495-503. ⟨10.1007/s00431-020-03859-2⟩ 2021, 180 (2), pp.495-503. ⟨10.1007/s00431-020-03859-2⟩ |
| بيانات النشر: | Springer Science and Business Media LLC, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Hypersensitivity, Immediate, Drug, medicine.medical_specialty, Allergy, medicine.drug_class, [SDV]Life Sciences [q-bio], media_common.quotation_subject, Antibiotics, Provocation test, Drug allergy, Penicillins, Drug Hypersensitivity, Pharmacovigilance, 03 medical and health sciences, 0302 clinical medicine, 030225 pediatrics, Internal medicine, medicine, Humans, 030212 general & internal medicine, Child, Retrospective Studies, Skin Tests, media_common, business.industry, medicine.disease, Anti-Bacterial Agents, 3. Good health, Hypersensitivity reaction, Penicillin, Pediatrics, Perinatology and Child Health, business, medicine.drug |
| الوصف: | International audience; Our objective was to describe and discuss management of recent cases of drug hypersensitivity in children reported in a pharmacovigilance center. Two pediatric allergy units conducted a collaborative retrospective analysis of 101 adverse drug reactions reported to a regional pharmacovigilance center between January 2016 and July 2019. Time lapse between hypersensitivity reaction onset and allergy consultation varied from 1 month to 12 years. Sixty-two patients (61.4%) presented with immediate reactions, 11 (10.9%) with non-immediate reactions, and 28 (27.7%) had reactions impossible to classify through medical interview. Overall, 92 children (91%) were explored for simultaneously administered drugs. All 113 prick tests were negative, and 2 were uncertain. Among 108 intradermal tests, 2 were positive to penicillin and to an iodinated contrast medium, 105 were negative, and 1 was uncertain. Overall, 129 drug provocation tests were proposed. Nine provocation tests among 80 were positive (11.25%): 6 to penicillin, 1 to sulfonamide antibiotics, and 2 to non-steroidal anti-inflammatory drugs; the remaining 71 were negative. No severe reaction was observed during these tests. Finally, drug allergy was only retained in 11 reported cases (10.9%). Conclusion: These pharmacovigilance reports show the difficulty in defining drug allergy in children only by anamnesis, and that explorations, particularly provocation tests, should take place at a reasonable time lapse after drug hypersensitivity reaction onset. What is Known: True drug allergy is rarely observed in children. Absence of full workup leads to falsely labeling children as ``allergic.'' What is New: Short time lapse between hypersensitivity onset and consultation improves classification of pediatric allergy. Timely allergy consultations are essential, and tests are useful to confirm or exclude pediatric allergy. |
| تدمد: | 1432-1076 0340-6199 |
| DOI: | 10.1007/s00431-020-03859-2 |
| DOI: | 10.1007/s00431-020-03859-2⟩ |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61f2da0c81765f557fd68a7e3b8e4e27 https://doi.org/10.1007/s00431-020-03859-2 |
| Rights: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....61f2da0c81765f557fd68a7e3b8e4e27 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14321076 03406199 |
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| DOI: | 10.1007/s00431-020-03859-2 |