A Pseudo-Outbreak due toAcinetobacterSpecies (GIM-1) Contamination of the Pneumatic Transport System of a Large University Hospital
| العنوان: | A Pseudo-Outbreak due toAcinetobacterSpecies (GIM-1) Contamination of the Pneumatic Transport System of a Large University Hospital |
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| المؤلفون: | Lutz von Müller, Sven Jungmann, Alexander Halfmann, Barbara Gärtner, Sören Gatermann, Mathias Herrmann, Alik Dawson, Martin Kaase |
| المصدر: | Infection Control & Hospital Epidemiology. 35:1364-1372 |
| بيانات النشر: | Cambridge University Press (CUP), 2014. |
| سنة النشر: | 2014 |
| مصطلحات موضوعية: | Adult, 0301 basic medicine, Microbiology (medical), medicine.medical_specialty, Adolescent, Epidemiology, 030106 microbiology, Microbial Sensitivity Tests, Disease cluster, beta-Lactam Resistance, beta-Lactamases, Disease Outbreaks, Hospitals, University, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Bacterial Proteins, Germany, Acinetobacter radioresistens, medicine, Humans, Infection control, 030212 general & internal medicine, Child, Intensive care medicine, Genotyping, Aged, Retrospective Studies, Acinetobacter, biology, business.industry, Infant, Newborn, Outbreak, Middle Aged, Contamination, biology.organism_classification, Infectious Diseases, Carbapenems, Emergency medicine, Equipment Contamination, Hospital Communication Systems, business, Acinetobacter Infections |
| الوصف: | Objective.To establish the source and contamination routes resulting in positive clinical and surveillance microbiological cultures with carbapenem-resistant, GIM-1 metallo-β-lactamase–positiveAcinetobacter pitiiandAcinetobacter radioresistensfrom 21 patients in 8 departmentsDesign.Retrospective, descriptive study.Setting.A 1,300-bed tertiary care academic medical facility consisting of 90 buildings linked by a pneumatic transport system (PTS).Methods.Microbiological workup of the cluster strains included matrix-assisted laser desorption/ionization time-of-flight species identification, phenotypic carbapenemase tests, polymerase chain reaction–based genotyping of carbapenemase, and pulsed-field gel electrophoresis. Outbreak management procedures were employed according to institutional regulations.Results.The rarity of GIM-1Acinetobacterspecies in the hospital and region, the lack of epidemiological links between patients, and the fact that in some patients the apparent colonization was clearly nonnosocomial prompted the suspicion of a pseudo-outbreak. Numerous environmental cultures were positive for GIM-1-positiveAcinetobacter(including archived sample requisition forms, PTS capsules, cultures from line-diverter and dispenser stations, and sterilized transport capsules following PTS delivery). Moreover, it was observed that condensation fluid from subterranean PTS tubing resulted in water entry in PTS capsules, possibly conferring specimen contamination. After extensive system disinfection, environmental surveys of the PTS were negative, and no further positive patient specimens were encountered.Conclusions.This is the first report of a PTS-associated pseudo-outbreak. The large number of falsely positive patient-related specimens in conjunction with the potential hazard of airborne and contact spread of multidrug-resistant microorganisms (in this case, GIM-1 carbapenem-resistantAcinetobacterspecies) underscores the need for implementation of infection control–based monitoring and operating procedures in a hospital PTS. |
| تدمد: | 1559-6834 0899-823X |
| DOI: | 10.1086/678413 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::613565c27c53ca811da7d9b4e68432af https://doi.org/10.1086/678413 |
| Rights: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....613565c27c53ca811da7d9b4e68432af |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15596834 0899823X |
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| DOI: | 10.1086/678413 |