Common functional alterations identified in blood transcriptome of autoimmune cholestatic liver and inflammatory bowel diseases
| العنوان: | Common functional alterations identified in blood transcriptome of autoimmune cholestatic liver and inflammatory bowel diseases |
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| المؤلفون: | Joanna Musialik, Jaroslaw Kierkus, Piotr Radwan, Bartosz Korczowski, Magdalena Piątkowska, Filip Ambrozkiewicz, Agnieszka Paziewska, Maria Janiak, Balabas Aneta, Michal Mikula, Anna Kluska, Michalina Dąbrowska, Maria Kulecka, Halina Cichoż-Lach, Natalia Żeber-Lubecka, Agnieszka Rogowska, Krzysztof Mucha, Jerzy Ostrowski, Izabella Lazowska-Przeorek, Jakub Karczmarski, Teresa Starzyńska |
| المصدر: | Scientific Reports Scientific Reports, Vol 9, Iss 1, Pp 1-11 (2019) |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | 0301 basic medicine, Male, Microarray, lcsh:Medicine, Disease, Transcriptome, 0302 clinical medicine, Gene Regulatory Networks, lcsh:Science, Child, Whole blood, Oligonucleotide Array Sequence Analysis, Regulation of gene expression, Multidisciplinary, Liver Cirrhosis, Biliary, Primary sclerosing cholangitis, Middle Aged, Ulcerative colitis, Crohn's disease, Primary biliary cirrhosis, Child, Preschool, Female, Adult, Adolescent, Cholangitis, Sclerosing, digestive system, Article, 03 medical and health sciences, Young Adult, medicine, Humans, RNA, Messenger, Aged, business.industry, Gene Expression Profiling, lcsh:R, Case-control study, Infant, medicine.disease, Inflammatory Bowel Diseases, digestive system diseases, 030104 developmental biology, Gene Expression Regulation, Case-Control Studies, Immunology, lcsh:Q, business, 030217 neurology & neurosurgery |
| الوصف: | Primary biliary cholangitis (PBC), primary sclerosing cholangitis (PSC), and inflammatory bowel diseases (IBDs), including Crohn’s disease (CD) and ulcerative colitis (UC), are heterogeneous chronic autoimmune diseases that may share underlying pathogenic mechanisms. Herein, we compared simultaneously analyzed blood transcriptomes from patients with PBC, PSC, and IBD. Microarray-based measurements were conducted using RNA isolated from whole blood samples from 90, 45, 95 and 93 patients with PBC, PSC, CD, and UC, respectively, and 47 healthy controls. Expression levels of selected transcripts were analyzed by quantitative reverse-transcribed PCR using an independent cohort of 292, 71 and 727 patients with PBC, PSC, and IBD, respectively. Of 4026, 2650 and 4967 probe sets differentially expressed (adjusted p-value |
| تدمد: | 2045-2322 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61038e5ce49499603607c81c7b00e0e1 https://pubmed.ncbi.nlm.nih.gov/31076612 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....61038e5ce49499603607c81c7b00e0e1 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20452322 |
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