High Levels of Polypharmacy in Rheumatoid Arthritis—A Challenge Not Covered by Current Management Recommendations: Data From a Large Real-Life Study
| العنوان: | High Levels of Polypharmacy in Rheumatoid Arthritis—A Challenge Not Covered by Current Management Recommendations: Data From a Large Real-Life Study |
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| المؤلفون: | Rodrigo Balbino Chaves Amorim, Paulo Louzada Júnior, Manoel Barros Bertolo, Claiton Viegas Brenol, Fernanda Maria Borghi, Nathália de Carvalho Sacilotto, Marcel Lobato Sauma, Ana Paula Monteiro Gomides, Sebastião Cezar Radominski, Ana Beatriz Vargas Santos, Cleandro Pires de Albuquerque, Maria Fernanda Brandão Resende Guimarães, Licia Maria Henrique Mota, Gustavo Gomes Resende, Isabela Araújo Santos, Henrique Carriço, Ivânio Alves Pereira, M. Sauma, Gláucio Ricardo Werner de Castro, Ricardo Machado Xavier, Rina Dalva Neubarth Giorgi, Maria Raquel da Costa Pinto, Karina Bonfiglioli, Geraldo da Rocha Castelar Pinheiro, Júlia Brito de Medeiros |
| المصدر: | Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual) Universidade de São Paulo (USP) instacron:USP |
| بيانات النشر: | SAGE Publications, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Male, medicine.medical_specialty, Comorbidity, Arthritis, Rheumatoid, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, medicine, Humans, Pharmacology (medical), 030212 general & internal medicine, Intensive care medicine, 030203 arthritis & rheumatology, Polypharmacy, business.industry, Middle Aged, medicine.disease, Rheumatology, COMORBIDADE, Cross-Sectional Studies, Increased risk, Current management, Antirheumatic Agents, Rheumatoid arthritis, Female, business, Life study |
| الوصف: | Background:Rheumatoid arthritis (RA) is associated with high frequency of comorbidities and increased risk of polypharmacy. Although there is a great potential for complications, there is a gap in literature on polypharmacy in patients with rheumatic arthritis.Objective:To evaluate the prevalence and factors associated with polypharmacy in a population in a real-life setting.Methods:A cross-sectional multicenter study was conducted in Brazil. Patients underwent clinical evaluation and medical records analysis. Polypharmacy was considered as a dependent variable. To test independent variables, we used Poisson regression.Results:We evaluated 792 patients (89% female, median age 56.6 years). Median duration of disease was 12.7 years, 78.73% had a positive rheumatoid factor. The median of disease activity score-28 was 3.5 (disease with mild activity), median of the clinical disease activity index score was 9, and median of health assessment questionnaire-disability index was 0.875; 47% used corticosteroids, 9.1% used nonsteroidal anti-inflammatory drugs, 90.9% used synthetic disease-modifying antirheumatic drugs, 35.7% used biologic disease-modifying antirheumatic drugs (DMARDs). In total, 537 (67.9%) patients used 5 or more drugs. Polypharmacy showed a relationship with a number of comorbidities and use of specific drugs (corticosteroids, methotrexate, and biological DMARDs).Conclusion:We found a high prevalence of polypharmacy (67.9%) in RA. Solutions to management this problem should be stimulated. |
| تدمد: | 1531-1937 0897-1900 |
| DOI: | 10.1177/0897190019869158 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::610361c35c81d37295545ebb184cac08 https://doi.org/10.1177/0897190019869158 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....610361c35c81d37295545ebb184cac08 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15311937 08971900 |
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| DOI: | 10.1177/0897190019869158 |