Ventral Tegmental Area Neurotensin Signaling Links the Lateral Hypothalamus to Locomotor Activity and Striatal Dopamine Efflux in Male Mice
| العنوان: | Ventral Tegmental Area Neurotensin Signaling Links the Lateral Hypothalamus to Locomotor Activity and Striatal Dopamine Efflux in Male Mice |
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| المؤلفون: | Christa M. Patterson, Gina M. Leinninger, Margaret B. Allison, Jenny Marie T. Wong, Robert T. Kennedy, Justin C. Jones, Omar S. Mabrouk, Alexander MacKenzie, Chelsea Kasper, Ian E. Gonzalez, Martin G. Myers |
| المصدر: | Endocrinology. 156:1692-1700 |
| بيانات النشر: | The Endocrine Society, 2015. |
| سنة النشر: | 2015 |
| مصطلحات موضوعية: | Male, medicine.medical_specialty, Lateral hypothalamus, Dopamine, Microdialysis, Motor Activity, Biology, Nucleus accumbens, Mass Spectrometry, Nucleus Accumbens, Neurotransmitter secretion, Mice, chemistry.chemical_compound, Endocrinology, Internal medicine, mental disorders, medicine, Animals, Neurotransmitter, Neurotensin, Original Research, Neurons, musculoskeletal, neural, and ocular physiology, Ventral Tegmental Area, Neostriatum, Ventral tegmental area, medicine.anatomical_structure, nervous system, chemistry, Hypothalamus, Hypothalamic Area, Lateral, psychological phenomena and processes, Signal Transduction, medicine.drug |
| الوصف: | Projections from the lateral hypothalamic area (LHA) innervate components of the mesolimbic dopamine (MLDA) system, including the ventral tegmental area (VTA) and nucleus accumbens (NAc), to modulate motivation appropriately for physiologic state. Neurotensin (NT)-containing LHA neurons respond to multiple homeostatic challenges and project to the VTA, suggesting that these neurons could link such signals to MLDA function. Indeed, we found that pharmacogenetic activation of LHA NT neurons promoted prolonged DA-dependent locomotor activity and NAc DA efflux, suggesting the importance of VTA neurotransmitter release by LHA NT neurons for the control of MLDA function. Using a microdialysis-mass spectrometry technique that we developed to detect endogenous NT in extracellular fluid in the mouse brain, we found that activation of LHA NT cells acutely increased the extracellular concentration of NT (a known activator of VTA DA cells) in the VTA. In contrast to the prolonged elevation of extracellular NAc DA, however, VTA NT concentrations rapidly returned to baseline. Intra-VTA infusion of NT receptor antagonist abrogated the ability of LHA NT cells to increase extracellular DA in the NAc, demonstrating that VTA NT promotes NAc DA release. Thus, transient LHA-derived NT release in the VTA couples LHA signaling to prolonged changes in DA efflux and MLDA function. |
| تدمد: | 1945-7170 0013-7227 |
| DOI: | 10.1210/en.2014-1986 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60b0df16a197134c1552c7c1c7dcbc31 https://doi.org/10.1210/en.2014-1986 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....60b0df16a197134c1552c7c1c7dcbc31 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19457170 00137227 |
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| DOI: | 10.1210/en.2014-1986 |