Autoantibody response to a novel tumor-associated antigen p90/CIP2A in breast cancer immunodiagnosis
| العنوان: | Autoantibody response to a novel tumor-associated antigen p90/CIP2A in breast cancer immunodiagnosis |
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| المؤلفون: | Jianying Zhang, Jitian Li, Xinxin Liu, Yurong Chai, Wenjie Li, Pengfei Ren, Mei Liu, Wei Qian, Liping Dai |
| المصدر: | Tumor Biology. 35:2661-2667 |
| بيانات النشر: | Springer Science and Business Media LLC, 2014. |
| سنة النشر: | 2014 |
| مصطلحات موضوعية: | Blotting, Western, Breast Neoplasms, Enzyme-Linked Immunosorbent Assay, Biology, Autoantigens, Article, Breast cancer screening, Breast cancer, Antigen, Antigens, Neoplasm, Biomarkers, Tumor, medicine, Humans, Stage (cooking), Autoantibodies, medicine.diagnostic_test, Intracellular Signaling Peptides and Proteins, Autoantibody, Membrane Proteins, General Medicine, medicine.disease, Immunohistochemistry, Blot, Tissue Array Analysis, Immunology, Female, AUTOANTIBODY RESPONSE |
| الوصف: | There is an urgent need to identify relevant tumor markers showing high sensitivity and specificity for early immunodiagnosis of breast cancer. Autoantibodies directed against tumor-associated antigens (TAAs) have been shown to be relevant tumor markers. The purpose of this study was to evaluate whether autoantibodies to a tumor-associated antigen p90/CIP2A can be used as diagnostic markers in breast cancer. In this study, autoantibody responses to p90/CIP2A were evaluated by enzyme-linked immunosorbent assay (ELISA), western blotting, and indirect immunofluorescence assay in sera from patients with breast cancer and normal human individuals. The results have demonstrated that p90/CIP2A can induce a relatively higher frequency of autoantibody response in breast cancer (19.1 %) compared to the sera of normal individuals (2.3 %). The frequency of p90/CIP2A expression in breast cancer tissues was significantly higher than that in adjacent normal tissues (P |
| تدمد: | 1423-0380 1010-4283 |
| DOI: | 10.1007/s13277-013-1350-6 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6067234e8dd041f4e1d5297c6fbdc77d https://doi.org/10.1007/s13277-013-1350-6 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....6067234e8dd041f4e1d5297c6fbdc77d |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14230380 10104283 |
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| DOI: | 10.1007/s13277-013-1350-6 |