Clinical impact of less invasive surfactant administration using video laryngoscopy in extremely preterm infants
| العنوان: | Clinical impact of less invasive surfactant administration using video laryngoscopy in extremely preterm infants |
|---|---|
| المؤلفون: | Michelle Baczynski, Veena Deekonda, Lisa Hamilton, Brittany Lindsay, Xiang Y. Ye, Amish Jain |
| المصدر: | Pediatric Research. 93:990-995 |
| بيانات النشر: | Springer Science and Business Media LLC, 2022. |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Pediatrics, Perinatology and Child Health |
| الوصف: | Examine the real-world clinical impact of adopting less invasive surfactant administration (LISA) as the primary surfactant administration method in extremely preterm infants.Single-center pre-post cohort study conducted over a 4-year period comparing outcomes of spontaneously breathing inborn infants 24GA and birth weight were 27.1 (26, 28.1) weeks and 914 (230) g, and 27.1 (26.1, 28.1) weeks and 920 (236) g for pre- and post-cohorts, respectively. Pre-cohort had higher C-section rates, (67% vs. 51%, p = 0.03). After adjustment for covariates, LISA was associated with reduced IMV exposure [AOR (95% CI) 0.07 (0.04, 0.11)], lower odds of the composite clinical outcome [0.49 (0.33, 0.73)], and most of its individual components.Real-world experience favors LISA as the primary method in extremely preterm infants with established spontaneous respiration.Less invasive surfactant administration (LISA) is associated with a reduction in respiratory morbidity, but real-world data of routine use among extremely preterm infants are limited. LISA is associated with reduced frequency of exposure to and duration of IMV in both ≤72 h after birth and during hospital stay. LISA is associated with a reduction in mortality, and most other major morbidities including bronchopulmonary dysplasia, and interventricular hemorrhage. Data from a large North American center providing real-world clinical outcomes following LISA as the primary method of surfactant administration. |
| تدمد: | 1530-0447 0031-3998 |
| DOI: | 10.1038/s41390-022-02197-3 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::605a20fc6c0e62744e230ed128a03d27 https://doi.org/10.1038/s41390-022-02197-3 |
| Rights: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....605a20fc6c0e62744e230ed128a03d27 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15300447 00313998 |
|---|---|
| DOI: | 10.1038/s41390-022-02197-3 |