Effect of remote ischaemic conditioning on infarct size and remodelling in ST-segment elevation myocardial infarction patients:the CONDI-2/ERIC-PPCI CMR substudy
| العنوان: | Effect of remote ischaemic conditioning on infarct size and remodelling in ST-segment elevation myocardial infarction patients:the CONDI-2/ERIC-PPCI CMR substudy |
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| المؤلفون: | Alexander Perkins, Richard Evans, Vanessa M Ferreira, Tushar Kotecha, Chiara Bucciarelli-Ducci, Rajesh K. Kharbanda, Thomas Engstrøm, Anthony Mathur, Matthew Dodd, Ulla Kristine Møller, Jun Chong, Derek J. Hausenloy, Hans Erik Bøtker, Tim Clayton, Rohin Francis, Roby Rakhit, Won Yong Kim, James C. Moon, John P Greenwood, Marianna Fontana, Derek M. Yellon, Heerajnarain Bulluck, Manish Ramlall, Jacob Lønborg |
| المصدر: | Francis, R, Chong, J, Ramlall, M, Bucciarelli-Ducci, C, Clayton, T, Dodd, M, Engstrøm, T, Evans, R, Ferreira, V M, Fontana, M, Greenwood, J P, Kharbanda, R K, Kim, W Y, Kotecha, T, Lønborg, J T, Mathur, A, Møller, U K, Moon, J, Perkins, A, Rakhit, R D, Yellon, D M, Bøtker, H E, Bulluck, H & Hausenloy, D J 2021, ' Effect of remote ischaemic conditioning on infarct size and remodelling in ST-segment elevation myocardial infarction patients : the CONDI-2/ERIC-PPCI CMR substudy ', Basic Research in Cardiology, vol. 116, no. 1, 59 . https://doi.org/10.1007/s00395-021-00896-2 Basic Research in Cardiology |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | medicine.medical_specialty, Magnetic Resonance Spectroscopy, Physiology, medicine.medical_treatment, Myocardial Infarction, Cardioprotection, Ventricular Function, Left, Myocardial infarct size, Percutaneous Coronary Intervention, Interquartile range, Physiology (medical), Internal medicine, hemic and lymphatic diseases, medicine, Clinical endpoint, Humans, ST segment, Single-Blind Method, Myocardial infarction, cardiovascular diseases, Ejection fraction, medicine.diagnostic_test, business.industry, Percutaneous coronary intervention, Stroke Volume, Magnetic resonance imaging, Original Contribution, medicine.disease, Treatment Outcome, Cuff, Cardiology, cardiovascular system, ST Elevation Myocardial Infarction, Cardiovascular magnetic resonance, Remote ischaemic conditioning, Cardiology and Cardiovascular Medicine, business, circulatory and respiratory physiology |
| الوصف: | The effect of limb remote ischaemic conditioning (RIC) on myocardial infarct (MI) size and left ventricular ejection fraction (LVEF) was investigated in a pre-planned cardiovascular magnetic resonance (CMR) substudy of the CONDI-2/ERIC-PPCI trial. This single-blind multi-centre trial (7 sites in UK and Denmark) included 169 ST-segment elevation myocardial infarction (STEMI) patients who were already randomised to either control (n = 89) or limb RIC (n = 80) (4 × 5 min cycles of arm cuff inflations/deflations) prior to primary percutaneous coronary intervention. CMR was performed acutely and at 6 months. The primary endpoint was MI size on the 6 month CMR scan, expressed as median and interquartile range. In 110 patients with 6-month CMR data, limb RIC did not reduce MI size [RIC: 13.0 (5.1–17.1)% of LV mass; control: 11.1 (7.0–17.8)% of LV mass, P = 0.39], or LVEF, when compared to control. In 162 patients with acute CMR data, limb RIC had no effect on acute MI size, microvascular obstruction and LVEF when compared to control. In a subgroup of anterior STEMI patients, RIC was associated with lower incidence of microvascular obstruction and higher LVEF on the acute scan when compared with control, but this was not associated with an improvement in LVEF at 6 months. In summary, in this pre-planned CMR substudy of the CONDI-2/ERIC-PPCI trial, there was no evidence that limb RIC reduced MI size or improved LVEF at 6 months by CMR, findings which are consistent with the neutral effects of limb RIC on clinical outcomes reported in the main CONDI-2/ERIC-PPCI trial. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 0300-8428 |
| DOI: | 10.1007/s00395-021-00896-2 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6056aa7c89afce7ebf5525e732a47c4a https://pure.au.dk/portal/da/publications/effect-of-remote-ischaemic-conditioning-on-infarct-size-and-remodelling-in-stsegment-elevation-myocardial-infarction-patients(8dbb67b5-61f7-48b8-92ae-3ac468f9c2f8).html |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....6056aa7c89afce7ebf5525e732a47c4a |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 03008428 |
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| DOI: | 10.1007/s00395-021-00896-2 |