Integration of a Raman spectroscopy system to a robotic-assisted surgical system for real-time tissue characterization during radical prostatectomy procedures
| العنوان: | Integration of a Raman spectroscopy system to a robotic-assisted surgical system for real-time tissue characterization during radical prostatectomy procedures |
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| المؤلفون: | Frederick Dallaire, Michael Pinto, Kevin C. Zorn, Chris Kent, Eric Marple, Frédéric Lesage, Dominique Trudel, Frederic Leblond, Joannie Desroches, Kelly Aubertin, Jean-Philippe Tremblay |
| المصدر: | Journal of Biomedical Optics |
| بيانات النشر: | Society of Photo-Optical Instrumentation Engineers, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Paper, Male, medicine.medical_specialty, Surgical margin, medicine.medical_treatment, Biomedical Engineering, Spectrum Analysis, Raman, 01 natural sciences, 010309 optics, Biomaterials, Prostate cancer, symbols.namesake, Robotic Surgical Procedures, In vivo, Prostate, Computer Systems, 0103 physical sciences, robotic surgery, medicine, Humans, Robotic surgery, General, Prostatectomy, business.industry, Phantoms, Imaging, Prostatic Neoplasms, Reproducibility of Results, Equipment Design, medicine.disease, prostate cancer, Atomic and Molecular Physics, and Optics, 3. Good health, Electronic, Optical and Magnetic Materials, medicine.anatomical_structure, Raman spectroscopy, symbols, Laparoscopy, Radiology, Positive Surgical Margin, Neoplasm Recurrence, Local, business |
| الوصف: | Surgical excision of the whole prostate through a radical prostatectomy procedure is part of the standard of care for prostate cancer. Positive surgical margins (cancer cells having spread into surrounding nonresected tissue) occur in as many as 1 in 5 cases and strongly correlate with disease recurrence and the requirement of adjuvant treatment. Margin assessment is currently only performed by pathologists hours to days following surgery and the integration of a real-time surgical readout would benefit current prostatectomy procedures. Raman spectroscopy is a promising technology to assess surgical margins: its in vivo use during radical prostatectomy could help insure the extent of resected prostate and cancerous tissue is maximized. We thus present the design and development of a dual excitation Raman spectroscopy system (680- and 785-nm excitations) integrated to the robotic da Vinci surgical platform for in vivo use. Following validation in phantoms, spectroscopic data from 20 whole human prostates immediately following radical prostatectomy are obtained using the system. With this dataset, we are able to distinguish prostate from extra prostatic tissue with an accuracy, sensitivity, and specificity of 91%, 90.5%, and 96%, respectively. Finally, the integrated Raman spectroscopy system is used to collect preliminary spectroscopic data at the surgical margin in vivo in four patients. |
| اللغة: | English |
| تدمد: | 1560-2281 1083-3668 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::600544338583761432ba383ed32da14e http://europepmc.org/articles/PMC6987653 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....600544338583761432ba383ed32da14e |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15602281 10833668 |
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