Sodium supply from administered blood products was associated with severe intraventricular haemorrhage in extremely preterm infants
| العنوان: | Sodium supply from administered blood products was associated with severe intraventricular haemorrhage in extremely preterm infants |
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| المؤلفون: | Cornelia Späth, Elisabeth Stoltz Sjöström, Johan Ågren, Fredrik Ahlsson, Magnus Domellöf |
| المصدر: | Acta Paediatrica. 111:1701-1708 |
| بيانات النشر: | Wiley, 2022. |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | transfusions, Sodium, intraventricular haemorrhage, Infant, Newborn, Pediatrik, Infant, Gestational Age, sodium supply, Infant, Premature, Diseases, General Medicine, Pediatrics, Case-Control Studies, Infant, Extremely Premature, Pediatrics, Perinatology and Child Health, sodium imbalances, Humans, preterm infants, Cerebral Hemorrhage |
| الوصف: | Aim The aim of this study was to investigate the associations between sodium supply, fluid volume, sodium imbalances and severe intraventricular haemorrhage (IVH) in extremely preterm (EPT) infants. Methods We used data from the EXtremely PREterm infants in Sweden Study (EXPRESS) cohort consisting of all infants born at 22 to 26 gestational weeks from 2004 to 2007 and conducted a nested case-control study. For every infant with severe IVH (grade 3 or peri-ventricular haemorrhagic infarction), one IVH-free control infant with the birthday closest to the case infant and matched for hospital, sex, gestational age and birth weight was selected (n = 70 case-control pairs). Results Total sodium supply and fluid volume were higher in infants with severe IVH compared with controls [daily total sodium supply until postnatal Day 2: mean +/- SD (mmol/kg/day): 5.49 +/- 2.53 vs. 3.95 +/- 1.91, p = 0.009]. These differences were accounted for by sodium and fluid from transfused blood products. High plasma sodium concentrations or large sodium fluctuations were not associated with severe IVH. Conclusion Our results suggest a relationship between sodium-rich transfusions of blood products and severe IVH in EPT infants. It is unclear whether this is an effect of sodium load, volume load or some other transfusion-related factor. |
| وصف الملف: | application/pdf |
| تدمد: | 1651-2227 0803-5253 |
| DOI: | 10.1111/apa.16423 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f918ef6e6083856a7684e262e8cb52b https://doi.org/10.1111/apa.16423 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....5f918ef6e6083856a7684e262e8cb52b |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 16512227 08035253 |
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| DOI: | 10.1111/apa.16423 |