Development and application of reverse genetic technology for the influenza virus
| العنوان: | Development and application of reverse genetic technology for the influenza virus |
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| المؤلفون: | Yong Huang, Ziquan Li, Liping Zhong, Yongxiang Zhao, Jian He |
| المصدر: | Virus Genes |
| بيانات النشر: | Springer US, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | medicine.medical_specialty, viruses, Biology, Virus, 03 medical and health sciences, Viral Proteins, Immune system, Medical microbiology, Virology, Influenza, Human, Genetics, medicine, Cytotoxic T cell, Animals, Humans, Reverse genetic technology, Molecular Biology, 030304 developmental biology, Infectivity, 0303 health sciences, Review Paper, 030306 microbiology, Transmission (medicine), virus diseases, General Medicine, Antitumor, Orthomyxoviridae, Reverse Genetics, Genetically modified organism, Oncolytic virus, Influenza virus, Vaccine |
| الوصف: | Influenza virus is a common virus in people's daily lives, and it has certain infectivity in humans and animals. Influenza viruses have the characteristics of a high mutation rate and wide distribution. Reverse genetic technology is primarily used to modify viruses at the DNA level through targeted modification of the virus cDNA. Genetically modified influenza viruses have a unique advantage when researching the transmission and pathogenicity of influenza. With the continuous development of oncolytic viruses in recent years, studies have found that influenza viruses also have certain oncolytic activity. Influenza viruses can specifically recognize tumor cells; activate cytotoxic T cells, NK cells, dendritic cells, etc.; and stimulate the body to produce an immune response, thereby killing tumor cells. This article will review the development and application of influenza virus reverse genetic technology. |
| اللغة: | English |
| تدمد: | 1572-994X 0920-8569 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f7cfec545d8971bd61b787b38bebfef http://europepmc.org/articles/PMC7851324 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....5f7cfec545d8971bd61b787b38bebfef |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 1572994X 09208569 |
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