Serum Biomarkers of Disease Activity in Longitudinal Assessment of Patients with ANCA-Associated Vasculitis
| العنوان: | Serum Biomarkers of Disease Activity in Longitudinal Assessment of Patients with ANCA-Associated Vasculitis |
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| المؤلفون: | Ulrich Specks, Gary S. Hoffman, Paul A. Monach, Peter A. Merkel, Kent J. Johnson, Robert Spiera, John H. Stone, Gunnar Tomasson, Carol A. Langford, Roscoe L. Warner, Robert A. Lew, Fernando C. Fervenza, E. William St. Clair, Philip Seo, Cees G. M. Kallenberg |
| المساهمون: | Translational Immunology Groningen (TRIGR) |
| المصدر: | ACR Open Rheumatology, Vol 4, Iss 2, Pp 168-176 (2022) ACR open rheumatology, 4(2), 168-176. Wiley |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | medicine.medical_specialty, Longitudinal study, ANTINEUTROPHIL CYTOPLASMIC ANTIBODIES, Inflammation, Diseases of the musculoskeletal system, Lipocalin, RELAPSE, Gastroenterology, WEGENERS-GRANULOMATOSIS, Rheumatology, Prednisone, Internal medicine, INJURY, medicine, Clinical significance, business.industry, Proportional hazards model, REMISSION, medicine.disease, C-REACTIVE PROTEIN, Clinical trial, RC925-935, medicine.symptom, FOLLOW-UP, business, Vasculitis, medicine.drug |
| الوصف: | Objective Improved biomarkers of current disease activity and prediction of relapse are needed in antineutrophil cytoplasmic antibody-associated vasculitis (AAV). For clinical relevance, biomarkers must perform well longitudinally in patients on treatment and in patients with nonsevere flares. Methods Twenty-two proteins were measured in 347 serum samples from 74 patients with AAV enrolled in a clinical trial. Samples were collected at Month 6 after remission induction, then every 3 months until Month 18, or at the time of flare. Associations of protein concentrations with concurrent disease activity and with future flare were analyzed using mixed-effects models, Cox proportional hazards models, and conditional logistic regression. Results Forty-two patients had flares during the 12-month follow-up period, and 32 remained in remission. Twenty-two patients had severe flares. Six experimental markers (CXCL13, IL-6, IL-8, IL-15, IL-18BP, and matrix metalloproteinase-3 [MMP-3]) and ESR were associated with disease activity using all three methods (P < 0.05, with P < 0.01 in at least one method). A rise in IL-8, IL-15, or IL-18BP was associated temporally with flare. Combining C-reactive protein (CRP), IL-18BP, neutrophil gelatinase-associated lipocalin (NGAL), and sIL-2R alpha improved association with active AAV. CXCL13 and MMP-3 were increased during treatment with prednisone, independent of disease activity. Marker concentrations during remission were not predictive of future flare. Conclusion Serum biomarkers of inflammation and tissue damage and repair have been previously shown to be strongly associated with severe active AAV were less strongly associated with active AAV in a longitudinal study that included mild flares and varying treatment. Markers rising contemporaneously with flare or with an improved association in combination merit further study. |
| وصف الملف: | application/pdf |
| تدمد: | 2578-5745 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5eec8a3a3de663b5d3b28089a93c44a6 https://pubmed.ncbi.nlm.nih.gov/34792864 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....5eec8a3a3de663b5d3b28089a93c44a6 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 25785745 |
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