Trends and prediction of antimicrobial susceptibility in urinary bacteria isolated in European emergency departments: The EuRoUtI 2010-2016 study
| العنوان: | Trends and prediction of antimicrobial susceptibility in urinary bacteria isolated in European emergency departments: The EuRoUtI 2010-2016 study |
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| المؤلفون: | Quentin Le Bastard, Loïc Brunard, Francesc Marco, S Laribi, Raymond Ruimy, Jérôme Robert, J P Romaszko, O Cores-Calvo, Ojetti, G Alvarez Corral, Pascale Bémer, F M Parrilla Ruiz, C Occelli, J M Gonzalez Del Castillo, L Dejoies, A Mencacci, C Piau-Couape, F Roman, H Bergmann, Alice Quaegebeur, P G Claret, Pierre-Nicolas Carron, Fihman, F Moustafa, S Q van Veen, M Pedersen, J Bonenfant, L Rossi, François Javaudin, C L Van Den Brand, Nicola Ramacciati, M Martinez Ortiz de Zarate, Pierre Hausfater, H Westh, Guy Prod'hom, F M Trovato, F Salvi, D Bieler, M F Lartigue, F J Candel Gonzalez, C Petruzziello, B Blumel, R Figueroa Ceron, Dario Tartaglia, Á Garcia-Garcia, M E Juvin, H Granzer, Jean-Philippe Lavigne, Gilbert Greub, Marie-Anne Vibet, P Dejaune, Eric Batard, Insa Joost, R Galeazzi, P Llorens, Emmanuel Montassier, M. Ortega, B Fiori, G Carpinteri |
| المساهمون: | Service des Urgences [CHU Nantes], Hôtel-Dieu de Nantes, Centre hospitalier universitaire de Nantes (CHU Nantes), Microbiotes, Hôtes, Antibiotiques et Résistances bactériennes (MiHAR) (MiHAR), Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN), Thérapeutiques cliniques et expérimentales des infections (EA 3826) (EA 3826), University of Puerto Rico at Mayaguez, UPRM, Institute of Earth Sciences Jaume Almera, Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), University of Barcelona, National Food Institute, Technical University of Denmark, Université de Lausanne (UNIL), Centre méditerranéen de médecine moléculaire (C3M), Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre Hospitalier Universitaire de Nîmes (CHU Nîmes), Service de médecine interne et d'immunologie clinique [CHU Pitié-Salpêtrière], CHU Pitié-Salpêtrière [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Centre Spatial de Liège (CSL), Université de Liège, CHU Pontchaillou [Rennes], IFIMUP (IFIMUP), Universidade do Porto, Centre de recherches en économie appliquée au développement (CREAD), Service de Département de médecine interne et immunologie clinique [CHU Pitié-Salpêtrière] (DMIIC) |
| المصدر: | Journal of Antimicrobial Chemotherapy Journal of Antimicrobial Chemotherapy, Oxford University Press (OUP), 2019, 74 (10), pp.3069-3076. ⟨10.1093/jac/dkz274⟩ |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | 0301 basic medicine, Microbiology (medical), Male, medicine.medical_specialty, Multivariate statistics, medicine.drug_class, [SDV]Life Sciences [q-bio], Urinary system, 030106 microbiology, Antibiotics, Cephalosporin, Antimicrobial susceptibility, Urine, Microbial Sensitivity Tests, antimicrobial susceptibility, Settore MED/07 - MICROBIOLOGIA E MICROBIOLOGIA CLINICA, 03 medical and health sciences, 0302 clinical medicine, Anti-Infective Agents, Patient age, Internal medicine, Drug Resistance, Bacterial, medicine, Humans, Pharmacology (medical), ComputingMilieux_MISCELLANEOUS, Aged, Retrospective Studies, Pharmacology, Aged, 80 and over, biology, Bacteria, business.industry, 030208 emergency & critical care medicine, Middle Aged, biology.organism_classification, urinary bacteria, 3. Good health, Anti-Bacterial Agents, Cephalosporins, Europe, Infectious Diseases, Cross-Sectional Studies, Female, business, Emergency Service, Hospital, Fluoroquinolones |
| الوصف: | Objectives To assess recent trends in susceptibility to antibiotics among urinary isolates isolated in European emergency departments (EDs) and to identify isolates with a high (90% or more) predicted probability of susceptibility to fluoroquinolones or third-generation cephalosporins (3GCs). Methods In this cross-sectional study, we included urine cultures obtained from adult patients between 2010 and 2016 in 24 European EDs. Temporal trends were assessed using time-series analysis and multivariate logistic models. Multivariate logistic models were also used to predict susceptibility to fluoroquinolones or 3GCs from patient age and sex, year, month and ED. Results We included 88242 isolates. Time-series analysis found a significant increase in susceptibility to fluoroquinolones and no significant trend for susceptibility to 3GCs. Adjusting for patient age and sex, ED and organism, multivariate models showed that susceptibility to 3GCs decreased from 2014 to 2016, while susceptibility to fluoroquinolones increased in 2015 and 2016. Among isolates from 2016, multivariate models predicted high probability of susceptibility to fluoroquinolones in 11% of isolates (positive predictive value 91%) and a high probability of susceptibility to 3GCs in 35% of isolates (positive predictive value 94%). Conclusions Susceptibility of ED urinary isolates to fluoroquinolones increased from 2014, while susceptibility to 3GCs decreased from 2015. Predictive models identified isolates with a high probability of susceptibility to fluoroquinolones or 3GCs. The ability of such models to guide the empirical treatment of pyelonephritis in the ED remains to be determined. |
| اللغة: | English |
| تدمد: | 0305-7453 1460-2091 |
| DOI: | 10.1093/jac/dkz274⟩ |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e59ce233a2d86e908734b438937b835 http://hdl.handle.net/11391/1460067 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....5e59ce233a2d86e908734b438937b835 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 03057453 14602091 |
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| DOI: | 10.1093/jac/dkz274⟩ |