Influenza vaccines: where we are, where we are going
| العنوان: | Influenza vaccines: where we are, where we are going |
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| المؤلفون: | Nadim, Khalil, David I, Bernstein |
| المصدر: | Current Opinion in Pediatrics. 34:119-125 |
| بيانات النشر: | Ovid Technologies (Wolters Kluwer Health), 2022. |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Influenza A Virus, H1N1 Subtype, Influenza Vaccines, SARS-CoV-2, Influenza A Virus, H3N2 Subtype, Pediatrics, Perinatology and Child Health, COVID-19, Humans, Pandemics |
| الوصف: | Influenza vaccines are the most useful strategy for preventing influenza illness, especially in the setting of the COVID-19 pandemic. For the coming year (2021/2022) all vaccines will be quadrivalent and contain two influenza A strains [(H1N1)pdm09-like and (H3N2)-like viruses] and two influenza B strains (Victoria lineage-like and Yamagata lineage-like viruses). However, the currently licensed have suboptimal efficacy due to the emergence of new strains and vaccine production limitations. In this review, we summarize the current recommendations as well as new advancements in influenza vaccinations.Recent advances have been aimed at moving away from egg-based vaccines and toward cell culture and recombinant vaccines. This removes egg adaptations that decrease vaccine efficacy, removes the reliance on egg availability and decreases the time necessary to manufacture vaccines. However, even more radical changes are needed if we are to reach the ultimate goal of a universal vaccine capable of providing long-lasting protection against all or at least most influenza strains. We discuss various strategies, including using more stable influenza antigens such as the hemagglutinin stalk and internal proteins as well as new adjuvants, new vaccine formulations, and DNA/RNA-based vaccines that are currently being developed.The currently available vaccines have suboptimal efficacy and do not provide adequate protection against drifted and shifted strains. Thus, the development of a universal influenza vaccine that induces long-lasing immunity and protects against a broad range of strains is crucial. |
| تدمد: | 1531-698X 1040-8703 |
| DOI: | 10.1097/mop.0000000000001103 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e2fb3f9f99f879e3851a1be56d5c54c https://doi.org/10.1097/mop.0000000000001103 |
| رقم الانضمام: | edsair.doi.dedup.....5e2fb3f9f99f879e3851a1be56d5c54c |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 1531698X 10408703 |
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| DOI: | 10.1097/mop.0000000000001103 |