Glial response to 17β-estradiol in neonatal rats with excitotoxic brain injury
| العنوان: | Glial response to 17β-estradiol in neonatal rats with excitotoxic brain injury |
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| المؤلفون: | Raffaella Moretti, Christiane Charriaut-Marlangue, Pierre Gressens, Jérôme Mairesse, Leslie Schwendimann, Jérémie Dalous, Assia Fafouri, Olivier Baud, Anne-Laure Schang, Didier Chevenne, Marina Colella, Julien Pansiot, Hoa Pham |
| المصدر: | Pansiot, J, Pham, H, Dalous, J, Chevenne, D, Colella, M, Schwendimann, L, Fafouri, A, Mairesse, J, Moretti, R, Schang, A-L, Charriaut-Marlangue, C, Gressens, P & Baud, O 2016, ' Glial response to 17β-estradiol in neonatal rats with excitotoxic brain injury ', Experimental Neurology, vol. 282, pp. 56-65 . https://doi.org/10.1016/j.expneurol.2016.05.024 Experimental Neurology, Vol. 282 (2016) pp. 56-65 |
| بيانات النشر: | Elsevier BV, 2016. |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | 0301 basic medicine, Cytokines/genetics/metabolism, Nerve Tissue Proteins/metabolism, Rats, Sprague-Dawley, 0302 clinical medicine, Leukoencephalopathies, Basic Helix-Loop-Helix Transcription Factors, Excitatory Amino Acid Agonists, Neurons/drug effects/metabolism, Cells, Cultured, Basic Helix-Loop-Helix Transcription Factors/metabolism, Cerebral Cortex, Neurons, Estradiol/pharmacology/therapeutic use, ddc:618, Estradiol, biology, Adenomatous Polyposis Coli Protein/metabolism, Neuroprotective Agents, medicine.anatomical_structure, Neurology, Cerebral cortex, Cytokines, Neuroglia, Plant Lectins, medicine.symptom, Leukoencephalopathies/chemically induced/therapy, Cerebral Cortex/cytology, Adenomatous Polyposis Coli Protein, Nerve Tissue Proteins, Inflammation, Brain damage, Excitatory Amino Acid Agonists/toxicity, Plant Lectins/metabolism, Neuroprotection, White matter, 03 medical and health sciences, Developmental Neuroscience, Neuroprotective Agents/pharmacology/therapeutic use, medicine, Animals, Neuroglia/drug effects/physiology, Ibotenic Acid, Dose-Response Relationship, Drug, Ibotenic Acid/toxicity, Myelin Basic Protein/metabolism, Myelin Basic Protein, Oligodendrocyte Transcription Factor 2, Embryo, Mammalian, Oligodendrocyte, Rats, Myelin basic protein, Disease Models, Animal, 030104 developmental biology, Animals, Newborn, biology.protein, Neuroscience, 030217 neurology & neurosurgery |
| الوصف: | White-matter injury is the most common cause of the adverse neurodevelopmental outcomes observed in preterm infants. Only few options exist to prevent perinatal brain injury associated to preterm delivery. 17β-estradiol (E2) is the predominant estrogen in circulation and has been shown to be neuroprotective in vitro and in vivo. However, while E2 has been found to modulate inflammation in adult models of brain damage, how estrogens influence glial cells response in the developing brain needs further investigations. Using a model of ibotenate-induced brain injury, we have refined the effects of E2 in the developing brain. E2 provides significant neuroprotection both in the cortical plate and the white matter in neonatal rats subjected to excitotoxic insult mimicking white matter and cortical damages frequently observed in very preterm infants. E2 promotes significant changes in microglial phenotypes balance in response to brain injury and the acceleration of oligodendrocyte maturation. Maturational effects of E2 on myelination process were observed both in vivo and in vitro. Altogether, these data demonstrate that response of glial cells to E2 could be responsible for its neuroprotective properties in neonatal excitotoxic brain injury. |
| وصف الملف: | application/pdf |
| تدمد: | 0014-4886 |
| DOI: | 10.1016/j.expneurol.2016.05.024 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e184f6e04eec96f4f71390795ad18d3 https://doi.org/10.1016/j.expneurol.2016.05.024 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....5e184f6e04eec96f4f71390795ad18d3 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 00144886 |
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| DOI: | 10.1016/j.expneurol.2016.05.024 |