التفاصيل البيبلوغرافية
العنوان:
Discovery of α-amidosulfones as potent and selective agonists of CB2: Synthesis, SAR, and pharmacokinetic properties
المؤلفون:
Ryan White , Erin F. DiMauro , Stephen Hitchcock , Robert T. Fremeau , Ming Y. Huang , Isaac E. Marx , Jason Brooks Human , Liyue Huang , Josie H. Lee , Alan C. Cheng , Vinod F. Patel , Xingwen Li , Matthew W. Martin , Renee Emkey
المصدر:
Bioorganic & Medicinal Chemistry Letters . 19:31-35
بيانات النشر:
Elsevier BV, 2009.
سنة النشر:
2009
مصطلحات موضوعية:
Chemistry , Organic Chemistry , Clinical Biochemistry , Pharmaceutical Science , Pharmacology , Amides , Biochemistry , Rats , Receptor, Cannabinoid, CB2 , Structure-Activity Relationship , Pharmacokinetics , Drug Discovery , Microsomes, Liver , Animals , Humans , Molecular Medicine , Sulfones , Molecular Biology
الوصف:
A series of α-amidosulfones were found to be potent and selective agonists of CB2. The discovery, synthesis, and structure–activity relationships of this series of agonists are reported. In addition, the pharmacokinetic properties of the most promising compounds are profiled.
تدمد:
0960-894X
DOI:
10.1016/j.bmcl.2008.11.026
URL الوصول:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e0daa5a47b3ce311b575c1293b5ea28 https://doi.org/10.1016/j.bmcl.2008.11.026
Rights:
CLOSED
رقم الانضمام:
edsair.doi.dedup.....5e0daa5a47b3ce311b575c1293b5ea28
قاعدة البيانات:
OpenAIRE