Morphological and functional aspects of acute kidney injury after fetal programing in the offspring of diabetic rats
| العنوان: | Morphological and functional aspects of acute kidney injury after fetal programing in the offspring of diabetic rats |
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| المؤلفون: | Laura Penna Rocha, Camila Souza de Oliveira Guimarães, Rosana Rosa Miranda Corrêa, Lenaldo Branco Rocha, Niels Olsen Saraiva Câmara, Luiz Carlos dos Reis, Marlene Antônia dos Reis, R. Gomes, Aldo Rogelis Aquiles Rodrigues, Carlos Donizete Pereira Júnior, Priscila Barbosa Idaló, Karla Roberta Martins Pucci, Ana Carolina Santana Pinheiro Moreira |
| المصدر: | The Journal of Maternal-Fetal & Neonatal Medicine. 28:403-408 |
| بيانات النشر: | Informa UK Limited, 2014. |
| سنة النشر: | 2014 |
| مصطلحات موضوعية: | medicine.medical_specialty, Offspring, Pregnancy in Diabetics, Renal function, Blood Pressure, Kidney, Kidney Function Tests, Streptozocin, Diabetes Mellitus, Experimental, Fetal Development, chemistry.chemical_compound, Heart Rate, Pregnancy, Diabetes mellitus, Internal medicine, medicine, Animals, Rats, Wistar, Creatinine, Fetus, business.industry, Acute kidney injury, Obstetrics and Gynecology, Acute Kidney Injury, medicine.disease, Rats, medicine.anatomical_structure, Endocrinology, chemistry, Prenatal Exposure Delayed Effects, Pediatrics, Perinatology and Child Health, Female, business |
| الوصف: | To evaluate the effects of folic acid (FA)-induced renal failure in young offspring of diabetic mothers.The offspring of streptozotocin-induced diabetic dams were divided into four groups: CC (controls receiving vehicle); DC (diabetics receiving vehicle); CA (controls receiving FA solution, 250 mg/kg) and DA (diabetics receiving FA solution, 250 mg/kg). Renal function tests and morphometry results were analyzed.An increase in creatinine and urea levels was observed in CA and DA groups at two and five months. FA administration caused a significant reduction in the number of glomeruli in the offspring of diabetic dams. The diabetes group treated with FA had fewer glomeruli compared to controls at two and five months. FA caused an increase in the area of the urinary space both in controls and offspring of diabetic dams at two and five months. The number of glomeruli and area of the urinary space at two months were negatively correlated.Fetal programing promotes remarkable changes in kidney morphology and function in offspring. We suggest that the morphological changes in the kidneys are more pronounced when fetal programing is associated with newly acquired diseases, e.g. renal failure induced by FA. |
| تدمد: | 1476-4954 1476-7058 |
| DOI: | 10.3109/14767058.2014.918097 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d9198c553d3193647e6d1f75ef2b192 https://doi.org/10.3109/14767058.2014.918097 |
| رقم الانضمام: | edsair.doi.dedup.....5d9198c553d3193647e6d1f75ef2b192 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14764954 14767058 |
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| DOI: | 10.3109/14767058.2014.918097 |