Asymptomatic Orthopoxvirus Circulation in Humans in the Wake of a Monkeypox Outbreak among Chimpanzees in Cameroon
| العنوان: | Asymptomatic Orthopoxvirus Circulation in Humans in the Wake of a Monkeypox Outbreak among Chimpanzees in Cameroon |
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| المؤلفون: | Elisabeth Dibongue, Ateba Athanase, Michael B. Townsend, Panayampalli Subbian Satheshkumar, Gordon Okpu, Sarah Anne J. Guagliardo, Christian Moundjoa, Andrea M. McCollum, Georges Alain Etoundi, Jillybeth Burgado, Mary G. Reynolds, Benjamin Monroe, Jeffrey B. Doty, Scott Epperson, Els Mathieu |
| المصدر: | The American Journal of Tropical Medicine and Hygiene |
| بيانات النشر: | American Society of Tropical Medicine and Hygiene, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Adult, Male, Adolescent, Pan troglodytes, 030231 tropical medicine, Orthopoxvirus, Antibodies, Viral, Asymptomatic, Disease Outbreaks, Serology, Young Adult, 03 medical and health sciences, Monkeypox, 0302 clinical medicine, Risk Factors, Virology, parasitic diseases, Odds Ratio, medicine, Animals, Humans, Cameroon, Young adult, biology, business.industry, virus diseases, Outbreak, Articles, Odds ratio, Middle Aged, biology.organism_classification, medicine.disease, Ape Diseases, Infectious Diseases, Immunoglobulin G, Monkeypox virus, Female, Parasitology, medicine.symptom, business |
| الوصف: | Monkeypox virus is a zoonotic Orthopoxvirus (OPXV) that causes smallpox-like illness in humans. In Cameroon, human monkeypox cases were confirmed in 2018, and outbreaks in captive chimpanzees occurred in 2014 and 2016. We investigated the OPXV serological status among staff at a primate sanctuary (where the 2016 chimpanzee outbreak occurred) and residents from nearby villages, and describe contact with possible monkeypox reservoirs. We focused specifically on Gambian rats (Cricetomys spp.) because they are recognized possible reservoirs and because contact with Gambian rats was common enough to render sufficient statistical power. We collected one 5-mL whole blood specimen from each participant to perform a generic anti-OPXV ELISA test for IgG and IgM antibodies and administered a questionnaire about prior symptoms of monkeypox-like illness and contact with possible reservoirs. Our results showed evidence of OPXV exposures (IgG positive, 6.3%; IgM positive, 1.6%) among some of those too young to have received smallpox vaccination (born after 1980, n = 63). No participants reported prior symptoms consistent with monkeypox. After adjusting for education level, participants who frequently visited the forest were more likely to have recently eaten Gambian rats (OR: 3.36, 95% CI: 1.91–5.92, P < 0.001) and primate sanctuary staff were less likely to have touched or sold Gambian rats (OR: 0.23, 95% CI: 0.19–0.28, P < 0.001). The asymptomatic or undetected circulation of OPXVs in humans in Cameroon is likely, and contact with monkeypox reservoirs is common, raising the need for continued surveillance for human and animal disease. |
| تدمد: | 1476-1645 0002-9637 |
| DOI: | 10.4269/ajtmh.19-0467 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d10467d0696586c011226f412419ef0 https://doi.org/10.4269/ajtmh.19-0467 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....5d10467d0696586c011226f412419ef0 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14761645 00029637 |
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| DOI: | 10.4269/ajtmh.19-0467 |