Physical and geometric determinants of transport in feto-placental microvascular networks
| العنوان: | Physical and geometric determinants of transport in feto-placental microvascular networks |
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| المؤلفون: | Igor L. Chernyavsky, Alexander Erlich, Oliver E. Jensen, Philip L. Pearce, Romina Plitman Mayo |
| المصدر: | Erlich, A, Pearce, P, Plitman Mayo, R, Jensen, O & Chernyavsky, I 2019, ' Physical and geometric determinants of transport in feto-placental microvascular networks ', Science Advances, vol. 5, no. 4, eaav6326 . https://doi.org/10.1126/sciadv.aav6326 Science Advances |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Countercurrent exchange, Physiology, Placenta, Finite Element Analysis, FOS: Physical sciences, Computational fluid dynamics, Models, Biological, Diffusion, 03 medical and health sciences, 0302 clinical medicine, Robustness (computer science), Pregnancy, Humans, Physics - Biological Physics, Tissues and Organs (q-bio.TO), Research Articles, 030304 developmental biology, Physics, 0303 health sciences, Multidisciplinary, business.industry, Scalar (physics), SciAdv r-articles, Quantitative Biology - Tissues and Organs, Oxygen, Range (mathematics), Nonlinear system, Flow (mathematics), Terminal (electronics), Applied Sciences and Engineering, Biological Physics (physics.bio-ph), FOS: Biological sciences, embryonic structures, Microvessels, Female, Biological system, business, 030217 neurology & neurosurgery, Research Article |
| الوصف: | Key geometric factors that determine nutrient transport in the functional exchange unit of the human placenta are identified. Across mammalian species, solute exchange takes place in complex microvascular networks. In the human placenta, the primary exchange units are terminal villi that contain disordered networks of fetal capillaries and are surrounded externally by maternal blood. We show how the irregular internal structure of a terminal villus determines its exchange capacity for diverse solutes. Distilling geometric features into three parameters, obtained from image analysis and computational fluid dynamics, we capture archetypal features of the structure-function relationship of terminal villi using a simple algebraic approximation, revealing transitions between flow- and diffusion-limited transport at vessel and network levels. Our theory accommodates countercurrent effects, incorporates nonlinear blood rheology, and offers an efficient method for testing network robustness. Our results show how physical estimates of solute transport, based on carefully defined geometrical statistics, provide a viable method for linking placental structure and function and offer a framework for assessing transport in other microvascular systems. |
| اللغة: | English |
| DOI: | 10.1126/sciadv.aav6326 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5cb1c42a88dc9a03d058d5500477f1a5 https://doi.org/10.1126/sciadv.aav6326 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....5cb1c42a88dc9a03d058d5500477f1a5 |
| قاعدة البيانات: | OpenAIRE |
| DOI: | 10.1126/sciadv.aav6326 |
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