Human tumors in immunocompetent mice
| العنوان: | Human tumors in immunocompetent mice |
|---|---|
| المؤلفون: | Brendan Horton, Shupei Zhang, Satyaki Sengupta, Haiting Ma, Bandana Sharma, Rudolf Jaenisch, Malkiel A. Cohen, Stefani Spranger, George W. Bell, Rani E. George |
| المصدر: | Cell Stem Cell PMC |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Xenotransplantation, medicine.medical_treatment, Cell, Population, Biology, Biochemistry, Article, 03 medical and health sciences, Mice, Neuroblastoma, 0302 clinical medicine, Immune system, Genetics, medicine, Cytotoxic T cell, Animals, Humans, Child, Induced pluripotent stem cell, education, Molecular Biology, 030304 developmental biology, Tumor microenvironment, 0303 health sciences, education.field_of_study, business.industry, Chimera, Neural crest, Cell Biology, medicine.disease, Disease Models, Animal, medicine.anatomical_structure, Neural Crest, Cancer research, Molecular Medicine, business, 030217 neurology & neurosurgery, Neoplasm Transplantation, Biotechnology |
| الوصف: | Summary Neuroblastoma (NB), derived from the neural crest (NC), is the most common pediatric extracranial solid tumor. Here, we establish a platform that allows the study of human NBs in mouse-human NC chimeras. Chimeric mice were produced by injecting human NC cells carrying NB relevant oncogenes in utero into gastrulating mouse embryos. The mice developed tumors composed of a heterogenous cell population that resembled that seen in primary NBs of patients but were significantly different from homogeneous tumors formed in xenotransplantation models. The human tumors emerged in immunocompetent hosts and were extensively infiltrated by mouse cytotoxic T cells, reflecting a vigorous host anti-tumor immune response. However, the tumors blunted the immune response by inducing infiltration of regulatory T cells and expression of immune-suppressive molecules similar to escape mechanisms seen in human cancer patients. Thus, this experimental platform allows the study of human tumor initiation, progression, manifestation, and tumor-immune-system interactions in an animal model system. |
| وصف الملف: | application/pdf |
| تدمد: | 1548-7105 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ca73854445c1a3973195804fa1d0052 https://pubmed.ncbi.nlm.nih.gov/32142683 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....5ca73854445c1a3973195804fa1d0052 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15487105 |
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