Cholinergic White Matter Lesions, AD-Signature Cortical Thickness, and Change in Cognition: The Northern Manhattan Study
| العنوان: | Cholinergic White Matter Lesions, AD-Signature Cortical Thickness, and Change in Cognition: The Northern Manhattan Study |
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| المؤلفون: | Tatjana Rundek, Noam Alperin, Clinton B. Wright, Karen L. Siedlecki, Ying Kuen Cheung, Mitchell S.V. Elkind, Sang H. Lee, Ralph L. Sacco, Michelle R. Caunca |
| المصدر: | J Gerontol A Biol Sci Med Sci |
| بيانات النشر: | Oxford University Press (OUP), 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Male, Aging, medicine.medical_specialty, Memory, Episodic, THE JOURNAL OF GERONTOLOGY: Medical Sciences, White matter lesion, Neuropsychological Tests, Cohort Studies, White matter, Executive Function, 03 medical and health sciences, Cognition, 0302 clinical medicine, Internal medicine, medicine, Humans, Multiple indicator, Gray Matter, Aged, 030304 developmental biology, Cerebral Cortex, Change score, 0303 health sciences, business.industry, Brain Cortical Thickness, Magnetic Resonance Imaging, White Matter, Hyperintensity, medicine.anatomical_structure, White matter hyperintensity, Cardiology, Cholinergic, Female, New York City, Geriatrics and Gerontology, business, 030217 neurology & neurosurgery |
| الوصف: | Background How cerebrovascular disease and neurodegeneration affect each other to impact cognition is not yet known. We aimed to test whether Alzheimer’s disease-signature (AD) cortical thickness mediates the association between cholinergic white matter lesion load and change in domain-specific cognition. Methods Clinically stroke-free participants from the Northern Manhattan Study with both regional white matter hyperintensity volume (WMHV) and gray matter measurements were included (N = 894). Tract-specific WMHVs were quantified through FSL using the Johns Hopkins University white matter tract atlas. We used Freesurfer 5.1 to estimate regional cortical thickness. We fit structural equation models, including multiple indicator latent change score models, to examine associations between white matter hyperintensity volume (WMHV) in cholinergic tracts, AD-signature region cortical thickness (CT), and domain-specific cognition. Results Our sample (N = 894) had a mean (SD) age = 70 (9) years, years of education = 10 (5), 63% women, and 67% Hispanics/Latinos. Greater cholinergic WMHV was significantly related to worse processing speed at baseline (standardized β = −0.17, SE = 0.05, p = .001) and over time (standardized β = −0.28, SE = 0.09, p = .003), with a significant indirect effect of AD-signature region CT (baseline: standardized β = −0.02, SE = 0.01, p = .023; change: standardized β = −0.03, SE = 0.02, p = .040). Conclusions Cholinergic tract WMHV is associated with worse processing speed, both directly and indirectly through its effect on AD-signature region CT. |
| تدمد: | 1758-535X 1079-5006 |
| DOI: | 10.1093/gerona/glz279 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c5d4c69c9201103e01831a024532f3a https://doi.org/10.1093/gerona/glz279 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....5c5d4c69c9201103e01831a024532f3a |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 1758535X 10795006 |
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| DOI: | 10.1093/gerona/glz279 |