Correction to: Brain-derived exosomes from dementia with Lewy bodies propagate α-synuclein pathology
| العنوان: | Correction to: Brain-derived exosomes from dementia with Lewy bodies propagate α-synuclein pathology |
|---|---|
| المؤلفون: | Anthony Adame, Eliezer Masliah, Ivy Trinh, Edward Rockenstein, Jennifer Ngolab, Deborah Masliah, Jazmin Florio, Margarita Trejo, Michael Mante, Robert A. Rissman |
| المصدر: | Acta neuropathologica communications, vol 8, iss 1 Acta Neuropathologica Communications, Vol 8, Iss 1, Pp 1-1 (2020) Acta Neuropathologica Communications |
| بيانات النشر: | eScholarship, University of California, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Male, 0301 basic medicine, Pathology, Exosomes, lcsh:RC346-429, 0302 clinical medicine, Florio, Alpha synuclein, Aged, 80 and over, Neurons, Philosophy, Brain, Endocytosis, Mice, Inbred DBA, alpha-Synuclein, Alzheimer’s disease, Lewy Body Disease, medicine.medical_specialty, Clinical Sciences, Protein Aggregation, Pathological, Pathology and Forensic Medicine, 03 medical and health sciences, Cellular and Molecular Neuroscience, Alzheimer Disease, Cell Line, Tumor, mental disorders, medicine, Animals, Humans, lcsh:Neurology. Diseases of the nervous system, Aged, Dementia with Lewy bodies, Research, Amyloid beta, Neurosciences, Correction, medicine.disease, Microvesicles, nervous system diseases, Rats, Mice, Inbred C57BL, Lewy body, 030104 developmental biology, nervous system, Astrocytes, Dementia, α synuclein, Neurology (clinical), Biochemistry and Cell Biology, Tau, 030217 neurology & neurosurgery |
| الوصف: | Proteins implicated in neurodegenerative conditions such as Alzheimer’s disease (AD) and Dementia with Lewy Bodies (DLB) have been identified in bodily fluids encased in extracellular vesicles called exosomes. Whether exosomes found in DLB patients can transmit pathology is not clear. In this study, exosomes were successfully harvested through ultracentrifugation from brain tissue from DLB and AD patients as well as non-diseased brain tissue. Exosomes extracted from brains diagnosed with either AD or DLB contained aggregate-prone proteins. Furthermore, injection of brain-derived exosomes from DLB patients into the brains of wild type mice induced α-synuclein (α-syn) aggregation. As assessed through immunofluorescent double labeling, α-syn aggregation was observed in MAP2+, Rab5+ neurons. Using a neuronal cell line, we also identified intracellular α-syn aggregation mediated by exosomes is dependent on recipient cell endocytosis. Together, these data suggest that exosomes from DLB patients are sufficient for seeding and propagating α-syn aggregation in vivo. |
| وصف الملف: | application/pdf |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c5a38a63e1247f3a5380d9ae7ad3c4b https://escholarship.org/uc/item/27k1b4dm |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....5c5a38a63e1247f3a5380d9ae7ad3c4b |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |