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Molecular patterns in deficient mismatch repair colorectal tumours: results from a French prospective multicentric biological and genetic study

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العنوان: Molecular patterns in deficient mismatch repair colorectal tumours: results from a French prospective multicentric biological and genetic study
المؤلفون: François-Noël Gilly, A. Abderrahim-Ferkoune, Houry S, Sylviane Olschwang, Daniel Benchimol, Patricia Formento, Jean-Luc Faucheron, Anne Sudaka, Valérie Boige, Bernard Pradère, M.P. Gaub, P. Lasser, A. Mahamat, Maurice Chazal, Jean-Robert Delpero, Gérard Milano, Denis Pezet, Jean-Louis Formento, Thierry André, Frédérique Penault-Llorca, Christian Letoublon, M. Etienne-Grimaldi, Pierre Laurent-Puig
المصدر: British Journal of Cancer
سنة النشر: 2013
مصطلحات موضوعية: Adult, Male, Cancer Research, Pathology, medicine.medical_specialty, Antimetabolites, Antineoplastic, Colorectal cancer, DNA Mutational Analysis, colorectal cancer, Kaplan-Meier Estimate, thymidylate synthase, Biology, Adenocarcinoma, medicine.disease_cause, Thymidylate synthase, DNA Mismatch Repair, Disease-Free Survival, medicine, Dihydropyrimidine dehydrogenase, Biomarkers, Tumor, Humans, Prospective Studies, Molecular Diagnostics, Dihydrouracil Dehydrogenase (NADP), Aged, Proportional Hazards Models, Aged, 80 and over, Polymorphism, Genetic, fluoropyrimidine, dihydropyrimidine dehydrogenase, Middle Aged, medicine.disease, mismatch repair, Oncology, Fluorouracil, Drug Resistance, Neoplasm, Cancer research, biology.protein, gene expression, DNA mismatch repair, Female, KRAS, France, Neoplasm Recurrence, Local, Colorectal Neoplasms, V600E, medicine.drug
الوصف: Background: To test the prognostic value of tumour protein and genetic markers in colorectal cancer (CRC) and examine whether deficient mismatch repair (dMMR) tumours had a distinct profile relative to proficient mismatch repair (pMMR) tumours. Methods: This prospective multicentric study involved 251 stage I–III CRC patients. Analysed biomarkers were EGFR (binding assay), VEGFA, thymidylate synthase (TS), thymidine phosphorylase (TP) and dihydropyrimidine dehydrogenase (DPD) expressions, MMR status, mutations of KRAS (codons 12–13), BRAF (V600E), PIK3CA (exons 9 and 20), APC (exon 15) and P53 (exons 4–9), CpG island methylation phenotype status, ploidy, S-phase, LOH. Results: The only significant predictor of relapse-free survival (RFS) was tumour staging. Analyses restricted to stage III showed a trend towards a shorter RFS in KRAS-mutated (P=0.005), BRAF wt (P=0.009) and pMMR tumours (P=0.036). Deficient mismatch repair tumours significantly demonstrated higher TS (median 3.1 vs 1.4) and TP (median 5.8 vs 3.5) expression relative to pMMR (P
تدمد: 1532-1827
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c41c5a23759b579393e253a032c6424
https://pubmed.ncbi.nlm.nih.gov/24800948
Rights: OPEN
رقم الانضمام: edsair.doi.dedup.....5c41c5a23759b579393e253a032c6424
قاعدة البيانات: OpenAIRE
الوصف
تدمد:15321827