An Overview of the Recent Development of Anticancer Agents Targeting the HIF-1 Transcription Factor
| العنوان: | An Overview of the Recent Development of Anticancer Agents Targeting the HIF-1 Transcription Factor |
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| المؤلفون: | Gouki Kambe, Tatsuya Suwa, Yukari Shirai, Hiroshi Harada, Minoru Kobayashi, Christalle C. T. Chow, Jin-Min Nam, Itsuki Takahashi |
| المصدر: | Cancers Cancers, Vol 13, Iss 2813, p 2813 (2021) |
| بيانات النشر: | MDPI, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | 0301 basic medicine, Cancer Research, Cancer therapy, Review, Biology, hypoxia-inducible factor 1 (HIF-1), HIF-1 inhibitor, 03 medical and health sciences, 0302 clinical medicine, Radioresistance, medicine, cancer, Treatment resistance, Transcription factor, RC254-282, tumor hypoxia, Tumor hypoxia, Cancer, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, chemoresistance, Adaptive response, Hypoxia (medical), medicine.disease, radioresistance, 030104 developmental biology, Oncology, 030220 oncology & carcinogenesis, Cancer research, medicine.symptom |
| الوصف: | Simple Summary As hypoxia-inducible factor 1 (HIF-1) is recognized as a target for cancer therapy, extensive efforts have been devoted to developing its inhibitors. We provide an overview of the latest information about basic, translational, and clinical research for the development of HIF-1 inhibitors. Abstract Hypoxia, a characteristic feature of solid tumors, is associated with the malignant phenotype and therapy resistance of cancers. Hypoxia-inducible factor 1 (HIF-1), which is responsible for the metazoan adaptive response to hypoxia, has been recognized as a rational target for cancer therapy due to its critical functions in hypoxic regions. In order to efficiently inhibit its activity, extensive efforts have been made to elucidate the molecular mechanism underlying the activation of HIF-1. Here, we provide an overview of relevant research, particularly on a series of HIF-1 activators identified so far and the development of anticancer drugs targeting them. |
| اللغة: | English |
| تدمد: | 2072-6694 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c314c5672dfadaf1fa495519d5e87c5 http://europepmc.org/articles/PMC8200185 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....5c314c5672dfadaf1fa495519d5e87c5 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20726694 |
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