Supplementary figures S1-S6, tables 1 and 2 from Mechanistic Dissection of PARP1 Trapping and the Impact on In Vivo Tolerability and Efficacy of PARP Inhibitors
التفاصيل البيبلوغرافية
العنوان:
Supplementary figures S1-S6, tables 1 and 2 from Mechanistic Dissection of PARP1 Trapping and the Impact on In Vivo Tolerability and Efficacy of PARP Inhibitors
American Association for Cancer Research (AACR), 2023.
سنة النشر:
2023
الوصف:
Supplementary figures S1-S6, tables 1 and 2. Table S1. Body weight loss and health observations in HeyA8 xenograft tumor-bearing mice treated with PARP inhibitors or TMZ alone or in combination. Table S2. Summary of PK parameters in HeyA8 xenograft tumor-bearing mice. Figure S1. PARP inhibitors potentiate the activity of alkylating agents in vitro. Figure S2. Equilibrium binding of PARP inhibitors to PARP1. Figure S3. Analysis of PARP1-DNA binding kinetics by BLI. Figure S4. Michaelis-Menten analysis of the mode of inhibition of different PARP inhibitors. Figure S5. γH2AX levels by cell cycle phase in HeyA8 cells treated with MMS and PARP inhibitors alone and in combination. Figure S6. Pharmacokinetics and pharmacodynamics in HeyA8 xenograft tumor-bearing mice.