التفاصيل البيبلوغرافية
العنوان:
Synthesis of thiosemicarbazone and 4-thiazolidinone derivatives and their in vitro anti-Toxoplasma gondii activity
المؤلفون:
José G. de Lima , Cristiane S. Carvalho , Rômulo P. Tenório , Edésio José Tenório de Melo , Alexandre José da Silva Góes , Carla de Sales Pessanha , Antonio J. Alves , Antônio Rodolfo de Faria
المصدر:
Bioorganic & Medicinal Chemistry Letters . 15:2575-2578
بيانات النشر:
Elsevier BV, 2005.
سنة النشر:
2005
مصطلحات موضوعية:
Thiosemicarbazones , Stereochemistry , Clinical Biochemistry , Antiprotozoal Agents , Nitro compound , Pharmaceutical Science , Biochemistry , Chemical synthesis , Apicomplexa , chemistry.chemical_compound , Chlorocebus aethiops , parasitic diseases , Drug Discovery , Animals , Vero Cells , Molecular Biology , Semicarbazone , chemistry.chemical_classification , biology , Organic Chemistry , Toxoplasma gondii , Biological activity , biology.organism_classification , In vitro , Thiazoles , chemistry , Molecular Medicine , Toxoplasma , Intracellular
الوصف:
Thiosemicarbazone and 4-thiazolidinone derivatives were synthesized in one and two step, respectively, from thiosemicarbazide, in satisfactory yields. Then, the synthesized compounds were submitted to evaluation against host cells infected with Toxoplasma gondii. The present studies showed that thiosemicarbazones 2 and 4-thiazolidinone derivatives 3 were effective against intracellular T. gondii.
تدمد:
0960-894X
DOI:
10.1016/j.bmcl.2005.03.048
URL الوصول:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b665c47337dbd32f0e3ebf282b63fac https://doi.org/10.1016/j.bmcl.2005.03.048
Rights:
CLOSED
رقم الانضمام:
edsair.doi.dedup.....5b665c47337dbd32f0e3ebf282b63fac
قاعدة البيانات:
OpenAIRE