Mastocytosis
| العنوان: | Mastocytosis |
|---|---|
| المؤلفون: | Katalin Kelemen, Rebecca L. King, Lisa M. Rimsza, Fiona E. Craig, Sa A. Wang, Kaaren K. Reichard, Hans-Peter Horny, Eric J. Duncavage, Tracy I. George, Leticia Quintanilla-Martinez, Attilio Orazi, Alexandar Tzankov |
| المصدر: | American Journal of Clinical Pathology. 155:239-266 |
| بيانات النشر: | Oxford University Press (OUP), 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Adult, Male, 0301 basic medicine, medicine.medical_specialty, Adolescent, Antineoplastic Agents, Tryptase, Hematologic Neoplasms, Diagnosis, Differential, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Mastocytosis, Systemic, medicine, Humans, Genetic Testing, Mast Cells, Child, Aged, biology, business.industry, Infant, Leukemia, Myelomonocytic, Chronic, Oncogenes, General Medicine, Middle Aged, Prognosis, Immunohistochemistry, Leukemia, Myeloid, Acute, Proto-Oncogene Proteins c-kit, 030104 developmental biology, 030220 oncology & carcinogenesis, Mutation, Immunology, Mutation (genetic algorithm), biology.protein, Female, Tryptases, Hematopathology, business, Mastocytosis |
| الوصف: | Objectives The 2019 Workshop of the Society for Hematopathology/European Association for Haematopathology received and reviewed cases covering the spectrum of mastocytosis and related diseases, including morphologic mimics, focusing on recent updates and relevant findings for pathologists. Methods The workshop panel reviewed 99 cases of cutaneous and systemic mastocytosis (SM) and SM and associated hematologic neoplasms (SM-AHN). Results Despite a common theme of KIT mutation (particularly D816V), mastocytosis is a heterogeneous neoplasm with a wide variety of presentations. This spectrum, including rare subtypes and extramedullary organ involvement, is discussed and illustrated by representative cases. Conclusions In the age of targeted treatment aimed at KIT, the accurate diagnosis and classification of mastocytosis has major implications for therapy and further interventions. Understanding the clinical, pathologic, and genetic findings of mastocytosis is crucial for selecting the proper tests to perform and subsequent arrival at a correct diagnosis in this rare disease. |
| تدمد: | 1943-7722 0002-9173 |
| DOI: | 10.1093/ajcp/aqaa183 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b2386da0302ff6c26bec5c7b1fb8e13 https://doi.org/10.1093/ajcp/aqaa183 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....5b2386da0302ff6c26bec5c7b1fb8e13 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19437722 00029173 |
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| DOI: | 10.1093/ajcp/aqaa183 |