Training with brain-machine interfaces, visuo-tactile feedback and assisted locomotion improves sensorimotor, visceral, and psychological signs in chronic paraplegic patients
| العنوان: | Training with brain-machine interfaces, visuo-tactile feedback and assisted locomotion improves sensorimotor, visceral, and psychological signs in chronic paraplegic patients |
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| المؤلفون: | Sabrina Esteves de Matos Almeida, Dora Fischer, Guillaume Bao, Vania A. S. Braga, Patricia B. Augusto, Mikhail A. Lebedev, Eduardo Joaquim Lopes Alho, Solaiman Shokur, Miguel A. L. Nicolelis, Ana R. C. Donati, Allen W. Song, Debora S. F. Campos, Christopher Petty, Claudia M. Gitti |
| المصدر: | PLoS ONE, Vol 13, Iss 11, p e0206464 (2018) PLoS ONE |
| بيانات النشر: | Public Library of Science (PLoS), 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | Male, 030506 rehabilitation, Muscle Physiology, Critical Care and Emergency Medicine, Physiology, medicine.medical_treatment, Social Sciences, Pathology and Laboratory Medicine, 0302 clinical medicine, Quality of life, Feedback, Sensory, Medicine and Health Sciences, Psychology, Spinal Cord Injury, Spinal cord injury, Musculoskeletal System, Trauma Medicine, Multidisciplinary, Rehabilitation, Physics, Neurological Rehabilitation, Classical Mechanics, Touch Perception, Neurology, Brain-Computer Interfaces, Physical Sciences, Legs, Medicine, Female, Sensory Perception, Anatomy, 0305 other medical science, Paraplegia, Traumatic Injury, Locomotion, Research Article, Muscle Contraction, Adult, medicine.medical_specialty, Science, Vibration, Rehabilitation Medicine, Pelvis, 03 medical and health sciences, Physical medicine and rehabilitation, Signs and Symptoms, Diagnostic Medicine, Sensation, medicine, Humans, Neurorehabilitation, Hip, Proprioception, business.industry, Biology and Life Sciences, Recovery of Function, medicine.disease, Body Limbs, Chronic Disease, Quality of Life, Lesions, Sexual function, business, Neurotrauma, 030217 neurology & neurosurgery, Neuroscience |
| الوصف: | Spinal cord injury (SCI) induces severe deficiencies in sensory-motor and autonomic functions and has a significant negative impact on patients’ quality of life. There is currently no systematic rehabilitation technique assuring recovery of the neurological impairments caused by a complete SCI. Here, we report significant clinical improvement in a group of seven chronic SCI patients (six AIS A, one AIS B) following a 28-month, multi-step protocol that combined training with non-invasive brain-machine interfaces, visuo-tactile feedback and assisted locomotion. All patients recovered significant levels of nociceptive sensation below their original SCI (up to 16 dermatomes, average 11 dermatomes), voluntary motor functions (lower-limbs muscle contractions plus multi-joint movements) and partial sensory function for several modalities (proprioception, tactile, pressure, vibration). Patients also recovered partial intestinal, urinary and sexual functions. By the end of the protocol, all patients had their AIS classification upgraded (six from AIS A to C, one from B to C). These improvements translated into significant changes in the patients’ quality of life as measured by standardized psychological instruments. Reexamination of one patient that discontinued the protocol after 12 months of training showed that the 16-month break resulted in neurological stagnation and no reclassification. We suggest that our neurorehabilitation protocol, based uniquely on non-invasive technology (therefore necessitating no surgical operation), can become a promising therapy for patients diagnosed with severe paraplegia (AIS A, B), even at the chronic phase of their lesion. |
| اللغة: | English |
| تدمد: | 1932-6203 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b07328735d2928e074a3b1259f61938 https://doaj.org/article/753fe889a03147e6ac688c4b2e5bd5f9 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....5b07328735d2928e074a3b1259f61938 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19326203 |
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