Design, Synthesis, and Structure−Activity Relationship of Trypanosoma brucei Leucyl-tRNA Synthetase Inhibitors as Antitrypanosomal Agents
| العنوان: | Design, Synthesis, and Structure−Activity Relationship of Trypanosoma brucei Leucyl-tRNA Synthetase Inhibitors as Antitrypanosomal Agents |
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| المؤلفون: | Michael Richard Kevin Alley, Jacob J. Plattner, Robert T. Jacobs, Dawei Li, Yaxue Zhao, Huchen Zhou, Qing Wang, Guo-Qiang Chen, Dazhong Ding, Fernando Rock, Qingqing Meng, Guangwei Gao, Bakela Nare |
| المصدر: | Journal of Medicinal Chemistry. 54:1276-1287 |
| بيانات النشر: | American Chemical Society (ACS), 2011. |
| سنة النشر: | 2011 |
| مصطلحات موضوعية: | Models, Molecular, Antiparasitic, medicine.drug_class, Stereochemistry, Trypanosoma brucei brucei, Trypanosoma brucei, Cell Line, Mice, Structure-Activity Relationship, chemistry.chemical_compound, Drug Discovery, medicine, Animals, Structure–activity relationship, African trypanosomiasis, chemistry.chemical_classification, biology, Leucyl-tRNA synthetase, Stereoisomerism, medicine.disease, biology.organism_classification, Boronic Acids, Trypanocidal Agents, Enzyme, chemistry, Biochemistry, Docking (molecular), Drug Design, Molecular Medicine, Leucine-tRNA Ligase, Growth inhibition |
| الوصف: | African trypanosomiasis, caused by the proto zoal pathogen Trypanosoma brucei (T. brucei), is one of the most neglected tropical diseases that are in great need of new drugs. We report the design and synthesis of T. brucei leucyl-tRNA synthetase (TbLeuRS) inhibitors and their structure--activity relationship. Benzoxaborole was used as the core structure and C(6) was modified to achieve improved affinity based on docking results that showed further binding space at this position. Indeed, compounds with C(7) substitutions showed diminished activity due to clash with the eukaryote specific I4ae helix while substitutions at C(6) gave enhanced affinity. TbLeuRS inhibitors with IC(50) as low as 1.6 μM were discovered, and the structure-activity relationship was discussed. The most potent enzyme inhibitors also showed excellent T. brucei parasite growth inhibition activity. This is the first time that TbLeuRS inhibitors are reported, and this study suggests that leucyl-tRNA synthetase (LeuRS) could be a potential target for antiparasitic drug development. |
| تدمد: | 1520-4804 0022-2623 |
| DOI: | 10.1021/jm101225g |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5afbd01304c63bacd1c89fe0b118fbbe https://doi.org/10.1021/jm101225g |
| رقم الانضمام: | edsair.doi.dedup.....5afbd01304c63bacd1c89fe0b118fbbe |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15204804 00222623 |
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| DOI: | 10.1021/jm101225g |