Endothelial Dysfunction and SARS-CoV-2 Infection: Association and Therapeutic Strategies
| العنوان: | Endothelial Dysfunction and SARS-CoV-2 Infection: Association and Therapeutic Strategies |
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| المؤلفون: | Hai Deng, Zhaohui Tang, Ting-Xuan Tang, Liang-Sheng Tang, Deng Chen, Xiang-Ping Yang |
| المصدر: | Pathogens, Vol 10, Iss 582, p 582 (2021) Pathogens |
| بيانات النشر: | MDPI AG, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | 0301 basic medicine, Microbiology (medical), Coronavirus disease 2019 (COVID-19), Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Blood fluidity, Inflammation, Review, 030204 cardiovascular system & hematology, endothelial dysfunction, 03 medical and health sciences, 0302 clinical medicine, Immune system, medicine, Immunology and Allergy, Respiratory system, Endothelial dysfunction, Molecular Biology, therapeutic strategies, General Immunology and Microbiology, business.industry, SARS-CoV-2, COVID-19, medicine.disease, Thrombosis, endothelial cells, 030104 developmental biology, Infectious Diseases, Immunology, Medicine, medicine.symptom, business |
| الوصف: | Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2), has been recently considered a systemic disorder leading to the procoagulant state. Preliminary studies have shown that SARS-CoV-2 can infect endothelial cells, and extensive evidence of inflammation and endothelial dysfunction has been found in advanced COVID-19. Endothelial cells play a critical role in many physiological processes, such as controlling blood fluidity, leukocyte activation, adhesion, platelet adhesion and aggregation, and transmigration. Therefore, it is reasonable to think that endothelial dysfunction leads to vascular dysfunction, immune thrombosis, and inflammation associated with COVID-19. This article summarizes the association of endothelial dysfunction and SARS-CoV-2 infection and its therapeutic strategies. |
| اللغة: | English |
| تدمد: | 2076-0817 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ae9697bd5520cfdccfcd444c6a76489 https://www.mdpi.com/2076-0817/10/5/582 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....5ae9697bd5520cfdccfcd444c6a76489 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20760817 |
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