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Local VEGF inhibition prevents ovarian alterations associated with ovarian hyperstimulation syndrome

التفاصيل البيبلوغرافية
العنوان: Local VEGF inhibition prevents ovarian alterations associated with ovarian hyperstimulation syndrome
المؤلفون: Leopoldina Scotti, Gabriela Fabiana Meresman, Natalia Pascuali, Dalhia Abramovich, Griselda Irusta, Fernanda Parborell, Marta Tesone
المصدر: The Journal of Steroid Biochemistry and Molecular Biology. 144:392-401
بيانات النشر: Elsevier BV, 2014.
سنة النشر: 2014
مصطلحات موضوعية: Vascular Endothelial Growth Factor A, CORPOREA LUTEA, medicine.medical_specialty, Angiogenesis, Recombinant Fusion Proteins, Endocrinology, Diabetes and Metabolism, Clinical Biochemistry, Ovarian hyperstimulation syndrome, Angiogenesis Inhibitors, Apoptosis, Biology, Occludin, Biochemistry, Human chorionic gonadotropin, Rats, Sprague-Dawley, Ciencias Biológicas, Ovarian Hyperstimulation Syndrome, Endocrinology, Internal medicine, medicine, Animals, Claudin-5, APOPTOSIS DRUG EFFECTS, Molecular Biology, Progesterone, Cell Proliferation, Vascular Endothelial Growth Factor Receptor-1, Estradiol, OVARIAN HTYPERSTIMULATION SYNDROME, urogenital system, Cell growth, Ovary, Endothelial Cells, Cell Biology, Bioquímica y Biología Molecular, medicine.disease, Vascular Endothelial Growth Factor Receptor-2, VEGF, Endothelial stem cell, Vascular endothelial growth factor A, Receptors, Vascular Endothelial Growth Factor, OCCLUDIN METABOLISM, cardiovascular system, Molecular Medicine, Female, CIENCIAS NATURALES Y EXACTAS
الوصف: The relationship between human chorionic gonadotropin and ovarian hyperstimulation syndrome (OHSS) is partially mediated by vascular endothelial growth factor A (VEGF). The aim of this study was to investigate the effects of VEGF inhibition on the development of corpora lutea (CL) and cystic structures, steroidogenesis, apoptosis, cell proliferation, endothelial cell area, VEGF receptors (KDR and Flt-1), claudin-5 and occludin levels in ovaries from an OHSS rat model. The VEGF inhibitor used (VEGF receptor-1 (FLT-1)/Fc chimera, TRAP) decreased the concentrations of progesterone and estradiol as well as the percentage of CL and cystic structures in OHSS rats, and increased apoptosis in CL. Endothelial cell area in CL and KDR expression and its phosphorylation were increased, whereas claudin-5 and occludin levels were decreased in the OHSS compared to the control TRAP reversed these parameters. Our findings indicate that VEGF inhibition prevents the early onset of OHSS and decreases its severity in rats. Fil: Scotti, Leopoldina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina Fil: Abramovich, Dalhia Nurit. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina Fil: Pascuali, Natalia Marisa. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina Fil: Irusta, Griselda. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina Fil: Meresman, Gabriela Fabiana. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina Fil: Tesone, Marta. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina Fil: Parborell, Maria Fernanda Agustina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina
وصف الملف: application/pdf
تدمد: 0960-0760
DOI: 10.1016/j.jsbmb.2014.08.013
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5acc74d37b7c1c0f63cfe03abd6af38d
https://doi.org/10.1016/j.jsbmb.2014.08.013
Rights: RESTRICTED
رقم الانضمام: edsair.doi.dedup.....5acc74d37b7c1c0f63cfe03abd6af38d
قاعدة البيانات: OpenAIRE
الوصف
تدمد:09600760
DOI:10.1016/j.jsbmb.2014.08.013