Commentary: cumulative risk assessment of perfluoroalkyl carboxylic acids and perfluoralkyl sulfonic acids: what is the scientific support for deriving tolerable exposures by assembling 27 PFAS into 1 common assessment group?
| العنوان: | Commentary: cumulative risk assessment of perfluoroalkyl carboxylic acids and perfluoralkyl sulfonic acids: what is the scientific support for deriving tolerable exposures by assembling 27 PFAS into 1 common assessment group? |
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| المؤلفون: | Thomas Colnot, Wolfgang Dekant |
| المصدر: | Archives of Toxicology. 96:3127-3139 |
| بيانات النشر: | Springer Science and Business Media LLC, 2022. |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Fluorocarbons, Alkanesulfonic Acids, Health, Toxicology and Mutagenesis, Carboxylic Acids, General Medicine, Sulfonic Acids, Toxicology, Risk Assessment |
| الوصف: | This commentary proposes an approach to risk assessment of mixtures of per- and polyfluorinated alkyl substances (PFAS) as EFSA was tasked to derive a tolerable intake for a group of 27 PFAS. The 27 PFAS to be considered contain different functional groups and have widely variable physicochemical (PC) properties and toxicokinetics and thus should not treated as one group based on regulatory guidance for risk assessment of mixtures. The proposed approach to grouping is to split the 27 PFAS into two groups, perfluoroalkyl carboxylates and perfluoroalkyl sulfonates, and apply a relative potency factor approach (as proposed by RIVM) to obtain two separate group TDIs based on liver toxicity in rodents since liver toxicity is a sensitive response of rodents to PFAS. Short chain PFAS and other PFAS structures should not be included in the groups due to their low potency and rapid elimination. This approach is in better agreement with scientific and regulatory guidance for mixture risk assessment. |
| تدمد: | 1432-0738 0340-5761 |
| DOI: | 10.1007/s00204-022-03336-9 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a5dfd96fe4041f1a6869c7212225b1d https://doi.org/10.1007/s00204-022-03336-9 |
| Rights: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....5a5dfd96fe4041f1a6869c7212225b1d |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14320738 03405761 |
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| DOI: | 10.1007/s00204-022-03336-9 |