Use of Cangrelor in Cervical and Intracranial Stenting for the Treatment of Acute Ischemic Stroke: A 'Real Life' Single-Center Experience
| العنوان: | Use of Cangrelor in Cervical and Intracranial Stenting for the Treatment of Acute Ischemic Stroke: A 'Real Life' Single-Center Experience |
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| المؤلفون: | Edoardo Boccardi, G. Barchetti, F. Ferrari, Luca Quilici, Amedeo Cervo, Mariangela Piano, Guglielmo Pero |
| المصدر: | AJNR Am J Neuroradiol |
| بيانات النشر: | American Society of Neuroradiology (ASNR), 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Adult, Male, medicine.medical_specialty, Cervical Artery, Arterial Occlusive Diseases, Single Center, 030218 nuclear medicine & medical imaging, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Cangrelor, Occlusion, medicine, Humans, Radiology, Nuclear Medicine and imaging, cardiovascular diseases, Aged, Cerebral Hemorrhage, Ischemic Stroke, Retrospective Studies, Thrombectomy, Aged, 80 and over, Intracerebral hemorrhage, Interventional, business.industry, Endovascular Procedures, Retrospective cohort study, Intracranial Artery, Middle Aged, medicine.disease, Adenosine Monophosphate, Surgery, Treatment Outcome, chemistry, Concomitant, Female, Stents, Neurology (clinical), business, Carotid Artery, Internal, Platelet Aggregation Inhibitors, 030217 neurology & neurosurgery |
| الوصف: | BACKGROUND AND PURPOSE: In cases of large-vessel-occlusion strokes due to an underlying tandem internal carotid artery occlusion or intracranial atherosclerotic disease, concomitant stent placement may be needed. Immediate platelet inhibition is necessary, but to date, a standardized approach for antiplatelet inhibition in acute settings is still missing. Here we report our single-center experience about the safety and efficacy of periprocedural administration of cangrelor in patients with acute ischemic stroke due to intracranial or cervical artery occlusion undergoing stent placement. MATERIALS AND METHODS: We retrospectively evaluated all cases of acute ischemic stroke that needed acute stent implantation and were treated with periprocedural administration of cangrelor between January 2019 and April 2020 at our institution. All patients who needed either extracranial or intracranial artery stent placement (in either the anterior or posterior circulation) were included. RESULTS: We evaluated 38 patients in whom cangrelor was administered IV periprocedurally. Their mean age was 64 years (range, 26–85 years), with 25/38 male subjects and 13/38 female patients. In 26 patients (68.4%), a tandem occlusion was present and was treated with carotid artery stent placement, while 12 patients (31.6%) required an intracranial stent implantation. In 4 subjects (10.5%), an intracerebral hemorrhage occurred after the procedure. All patients in the series were alive 1 week after the procedure. CONCLUSIONS: Although larger, multicentric randomized studies are strongly warranted, our results support the hypothesis of a possible role of cangrelor as a valuable therapeutic option in the management of platelet inhibition in acute ischemic stroke procedures after intra- or extracranial stent placement. |
| تدمد: | 1936-959X 0195-6108 |
| DOI: | 10.3174/ajnr.a6785 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59a0122fd112ceb9d8da2a707e0f5c2d https://doi.org/10.3174/ajnr.a6785 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....59a0122fd112ceb9d8da2a707e0f5c2d |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 1936959X 01956108 |
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| DOI: | 10.3174/ajnr.a6785 |