Association of circulating monocyte chemoattractant protein-1 levels with cardiovascular mortality: A meta-analysis of population-based studies
| العنوان: | Association of circulating monocyte chemoattractant protein-1 levels with cardiovascular mortality: A meta-analysis of population-based studies |
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| المؤلفون: | Caroline Sun, Ron C. Hoogeveen, Olle Melander, Tiberiu A Pana, Phyo K. Myint, James A. de Lemos, Lana Fani, Astrid Zierer, Colby Ayers, Barbara Thorand, Christie M. Ballantyne, Emelia J. Benjamin, Martin Dichgans, Christian Herder, Annette Peters, Maryam Kavousi, Mohamed A. Elhadad, Wolfgang Koenig, S. Matthijs Boekholdt, Jan Nilsson, Gunnar Engström, Rainer Malik, Josée Dupuis, Marju Orho-Melander, Marios K. Georgakis, Biqi Wang, Harry Björkbacka |
| المساهمون: | Epidemiology, ACS - Atherosclerosis & ischemic syndromes, Cardiology, ACS - Heart failure & arrhythmias |
| المصدر: | JAMA Cardiol. 6, 587-592 (2021) JAMA cardiology 6(5), 587-592 (2021). doi:10.1001/jamacardio.2020.5392 JAMA Cardiology, 6(5), 587-592. American Medical Association JAMA cardiology, 6(5), 587-592. American Medical Association JAMA Cardiol |
| بيانات النشر: | Amer Medical Assoc, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | medicine.medical_specialty, blood [Myocardial Infarction], Population, mortality [Cardiovascular Diseases], Disease, 030204 cardiovascular system & hematology, epidemiology [Coronary Disease], blood [Coronary Disease], 03 medical and health sciences, 0302 clinical medicine, SDG 3 - Good Health and Well-being, blood [Cardiovascular Diseases], Internal medicine, blood [Chemokine CCL2], medicine, Humans, 030212 general & internal medicine, Myocardial infarction, ddc:610, education, Proportional Hazards Models, education.field_of_study, Unstable angina, business.industry, Proportional hazards model, Brief Report, Hazard ratio, medicine.disease, epidemiology [Myocardial Infarction], 3. Good health, Meta-analysis, Cardiology, Cardiology and Cardiovascular Medicine, business, Cohort study |
| الوصف: | Importance: Human genetics and studies in experimental models support a key role of monocyte-chemoattractant protein-1 (MCP-1) in atherosclerosis. Yet, the associations of circulating MCP-1 levels with risk of coronary heart disease and cardiovascular death in the general population remain largely unexplored. Objective: To explore whether circulating levels of MCP-1 are associated with risk of incident coronary heart disease, myocardial infarction, and cardiovascular mortality in the general population. Data Sources and Selection: Population-based cohort studies, identified through a systematic review, that have examined associations of circulating MCP-1 levels with cardiovascular end points. Data Extraction and Synthesis: Using a prespecified harmonized analysis plan, study-specific summary data were obtained from Cox regression models after excluding individuals with overt cardiovascular disease at baseline. Derived hazard ratios (HRs) were synthesized using random-effects meta-analyses. Main Outcomes and Measures: Incident coronary heart disease (myocardial infarction, coronary revascularization, and unstable angina), nonfatal myocardial infarction, and cardiovascular death (from cardiac or cerebrovascular causes). Results: The meta-analysis included 7 cohort studies involving 21401 individuals (mean [SD] age, 53.7 [10.2] years; 10012 men [46.8%]). Mean (SD) follow-up was 15.3 (4.5) years (326392 person-years at risk). In models adjusting for age, sex, and race/ethnicity, higher MCP-1 levels at baseline were associated with increased risk of coronary heart disease (HR per 1-SD increment in MCP-1 levels: 1.06 [95% CI, 1.01-1.11]; P =.01), nonfatal myocardial infarction (HR, 1.07 [95% CI, 1.01-1.13]; P =.02), and cardiovascular death (HR, 1.12 [95% CI, 1.05-1.20]; P |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 2380-6583 |
| DOI: | 10.1001/jamacardio.2020.5392 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::596c14c5d7409abcf88d771eca401e55 https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=60534 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....596c14c5d7409abcf88d771eca401e55 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 23806583 |
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| DOI: | 10.1001/jamacardio.2020.5392 |