Sequelae of acute myocardial infarction regarding cardiac structure and function and their prognostic significance as assessed by magnetic resonance imaging
| العنوان: | Sequelae of acute myocardial infarction regarding cardiac structure and function and their prognostic significance as assessed by magnetic resonance imaging |
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| المؤلفون: | Olaf Grebe, Martin Höher, Hans A. Kestler, Jochen Wöhrle, Nico Merkle, Vinzenz Hombach, Matthias Kochs, Sebastian Waldenmaier |
| المصدر: | European Heart Journal. 26:549-557 |
| بيانات النشر: | Oxford University Press (OUP), 2005. |
| سنة النشر: | 2005 |
| مصطلحات موضوعية: | Male, Cardiac Catheterization, medicine.medical_specialty, Myocardial Infarction, Infarction, Coronary Angiography, Pericardial effusion, Disease-Free Survival, Pericarditis, Risk Factors, Internal medicine, medicine, Humans, cardiovascular diseases, Myocardial infarction, Ventricular remodeling, Aged, Ejection fraction, Ventricular Remodeling, medicine.diagnostic_test, business.industry, Heart, Magnetic resonance imaging, Middle Aged, Prognosis, medicine.disease, Magnetic Resonance Imaging, Cardiology, Regression Analysis, Female, Radiology, Cardiology and Cardiovascular Medicine, business, Mace, Follow-Up Studies |
| الوصف: | Aims Because of its high spatial resolution and tissue contrast, magnetic resonance imaging (MRI) was used to assess cardiac structure and function in a large population of patients with acute myocardial infarction (AMI). Methods and results One hundred and ten patients were studied by MRI 6.1±2.2 days after AMI. Infarct size (IS), persistent microvascular obstruction (PMO), left and right ventricular (LV/RV) volumes, and functions were measured. The same MRI measurements were repeated in 89 patients after a mean follow-up period of 225±92 days. IS was 11.9±7.3% of total LV muscle mass. PMO was detected in 51/110 (46.4%) patients and comprised 15.6±8.5% of IS and 2.8±2.3% of LV muscle mass. Papillary muscle infarct was seen in 26%, RV infarction in 16%, pericarditis in 40%, and pericardial effusion in 66% of the patients. During follow-up, there were 16 major adverse cardiac events (MACE) including seven deaths. IS, PMO, and amount of transmural infarction were predictive for LV adverse remodelling defined as >20% increase in LV end-diastolic volume. Multivariable analysis revealed LV end-diastolic volume, LV ejection fraction, and PMO as significant predictors for the occurrence of MACE. Conclusion MRI is a highly sensitive and reliable tool to detect morphologic and functional sequelae of AMI providing baseline MRI parameters with relevant predictive power for LV adverse remodelling and occurrence of MACE. |
| تدمد: | 1522-9645 0195-668X |
| DOI: | 10.1093/eurheartj/ehi147 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58aa6f1d9bdfe3009eb6a39cdc2a2260 https://doi.org/10.1093/eurheartj/ehi147 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....58aa6f1d9bdfe3009eb6a39cdc2a2260 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15229645 0195668X |
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| DOI: | 10.1093/eurheartj/ehi147 |