S1PR1 and VEGFR2 – a synergy that promotes tumor angiogenesis?
| العنوان: | S1PR1 and VEGFR2 – a synergy that promotes tumor angiogenesis? |
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| المؤلفون: | Zahid Akhter, Vigneshwaran Vellingiri, Dolly Mehta, Vijay Avin Balaji Ragunathrao, Mumtaz Anwar |
| المصدر: | Molecular & Cellular Oncology article-version (VoR) Version of Record |
| بيانات النشر: | Taylor & Francis, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | 0301 basic medicine, Tumor angiogenesis, cAbl1, Cancer Research, VEGF receptors, Tumor vascularization, 03 medical and health sciences, 0302 clinical medicine, Medicine, S1PR1, biology, business.industry, Antagonist, tumor angiogenesis, respiratory system, Endothelial stem cell, 030104 developmental biology, VEGFR2, 030220 oncology & carcinogenesis, Cancer research, biology.protein, cardiovascular system, Commentary, Molecular Medicine, business, circulatory and respiratory physiology, Article Commentary |
| الوصف: | We have recently uncovered that endothelial cell (EC) S1PR1 controls the effectiveness of VEGFR2 driven tumor angiogenesis. By using tumor ECs, EC-S1PR1−/- mice and S1PR1 antagonist, we showed that VEGF-VEGFR2 pathway requires EC-S1PR1-induced signaling to efficiently drive tumor vascularization and growth, indicating combining S1PR1 antagonist with anti-VEGF/VEGFR2 therapy may eradicate resistant tumors. |
| اللغة: | English |
| تدمد: | 2372-3556 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::589f9b87915388eaaf182e9cf186d6c4 http://europepmc.org/articles/PMC7469464 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....589f9b87915388eaaf182e9cf186d6c4 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 23723556 |
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