The role of mitochondrial ATP synthase in cancer
| العنوان: | The role of mitochondrial ATP synthase in cancer |
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| المؤلفون: | Chiara Galber, Manuel Jesús Acosta, Giovanni Minervini, Valentina Giorgio |
| المساهمون: | Galber C., Acosta M.J., Minervini G., Giorgio V. |
| المصدر: | Biological Chemistry. 401:1199-1214 |
| بيانات النشر: | Walter de Gruyter GmbH, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | 0301 basic medicine, Enzyme complex, ATP synthase, cancer, mitochondria, permeability transition, Clinical Biochemistry, Oxidative phosphorylation, Mitochondrion, Gene mutation, Biochemistry, Permeability transition, 03 medical and health sciences, 0302 clinical medicine, Neoplasms, Animals, Humans, Inner mitochondrial membrane, Molecular Biology, Cancer, chemistry.chemical_classification, biology, Mitochondrial Permeability Transition Pore, Proteins, Inhibitor protein, Mitochondrial Proton-Translocating ATPases, Mitochondria, Cell biology, Gene Expression Regulation, Neoplastic, Protein Subunits, 030104 developmental biology, Enzyme, chemistry, 030220 oncology & carcinogenesis, Mutation, biology.protein, Protein Modification, Translational |
| الوصف: | The mitochondrial ATP synthase is a multi-subunit enzyme complex located in the inner mitochondrial membrane which is essential for oxidative phosphorylation under physiological conditions. In this review, we analyse the enzyme functions involved in cancer progression by dissecting specific conditions in which ATP synthase contributes to cancer development or metastasis. Moreover, we propose the role of ATP synthase in the formation of the permeability transition pore (PTP) as an additional mechanism which controls tumour cell death. We further describe transcriptional and translational modifications of the enzyme subunits and of the inhibitor protein IF1 that may promote adaptations leading to cancer metabolism. Finally, we outline ATP synthase gene mutations and epigenetic modifications associated with cancer development or drug resistance, with the aim of highlighting this enzyme complex as a potential novel target for future anti-cancer therapy. |
| وصف الملف: | ELETTRONICO |
| تدمد: | 1437-4315 1431-6730 |
| DOI: | 10.1515/hsz-2020-0157 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57f2e8bbcb61f7783efb7177865f42c2 https://doi.org/10.1515/hsz-2020-0157 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....57f2e8bbcb61f7783efb7177865f42c2 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14374315 14316730 |
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| DOI: | 10.1515/hsz-2020-0157 |