Two-Step Approach Using Degradable Magnesium to Inhibit Surface Biofilm and Subsequently Kill Planktonic Bacteria
| العنوان: | Two-Step Approach Using Degradable Magnesium to Inhibit Surface Biofilm and Subsequently Kill Planktonic Bacteria |
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| المؤلفون: | Ren-Yi Wang, Wei-Ru Wang, Ling-Hua Chang, Jia-Lin Wu, Long-Sheng Lu, Jason S.C. Jang, Pei-Chun Wong, Tai-Yuan Su |
| المصدر: | Biomedicines Volume 9 Issue 11 Biomedicines, Vol 9, Iss 1677, p 1677 (2021) |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | QH301-705.5, Two step, Medicine (miscellaneous), chemistry.chemical_element, magnesium, biodegradation, General Biochemistry, Genetics and Molecular Biology, Article, biofilm, Microbiology, Biology (General), biology, Magnesium, Planktonic bacteria, fungi, Biofilm, bacterial infection, Biodegradation, biochemical phenomena, metabolism, and nutrition, biology.organism_classification, antibacterial, chemistry, Degradation (geology), alkaline, spalling, Bacteria |
| الوصف: | Bacterial infection remains a great risk in medical implantation surgery. In this paper, we found that degradable metals may be a feasible alternative option of antibacterial implantation materials. It is known that the spalling mechanism of magnesium (Mg) during degradation leads to Mg ions-induced alkaline environment, which is harmful to planktonic bacteria. In this study, we showed that alkaline pH environment is almost harmless to those adhesive bacteria protected in well-formed biofilms. Moreover, experimental results demonstrated that the biofilm formed in the place where Mg spalls are destroyed, releasing the covered bacteria to be planktonic in the alkaline environment. As a result, the colonization of biofilms continues to shrink during the degradation of Mg. It implies that if degradable metal is employed as implantation material, even if bacterial infection occurs, it may be possibly cured without second surgery. |
| وصف الملف: | application/pdf |
| تدمد: | 2227-9059 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57f2be768799e76988df7ee6771ab6ab https://pubmed.ncbi.nlm.nih.gov/34829908 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....57f2be768799e76988df7ee6771ab6ab |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 22279059 |
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