68Ga-radiolabeled AGuIX nanoparticles as dual-modality imaging agents for PET/MRI-guided radiation therapy
| العنوان: | 68Ga-radiolabeled AGuIX nanoparticles as dual-modality imaging agents for PET/MRI-guided radiation therapy |
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| المؤلفون: | Penelope Bouziotis, Anastasios Gaitanis, Eloise Thomas, Stavros Xanthopoulos, François Lux, Charles Truillet, Lia A. Moulopoulos, Dimitris Stellas, Vassilis Koutoulidis, Charalampos Tsoukalas, Theodoros Tsotakos, Maria Paravatou-Petsotas, Olivier Tillement, Constantinos Anagnostopoulos |
| المساهمون: | National Center for Scientific Research 'Demokritos' (NCSR), Department of Cancer Biology, Biomedical Research Foundation of the Academy of Athens, Institut Lumière Matière [Villeurbanne] (ILM), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS), First Department of Radiology, School of Medicine, National and Kapodistrian University of Athens (NKUA) |
| المصدر: | Nanomedicine Nanomedicine, Future Medicine, 2017, 12 (13), pp.1561-1574. ⟨10.2217/nnm-2017-0032⟩ |
| بيانات النشر: | Future Medicine Ltd, 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | Biodistribution, medicine.medical_specialty, Materials science, [SDV.IB.IMA]Life Sciences [q-bio]/Bioengineering/Imaging, medicine.medical_treatment, Biomedical Engineering, Medicine (miscellaneous), Bioengineering, [CHIM.THER]Chemical Sciences/Medicinal Chemistry, 02 engineering and technology, Development, 030218 nuclear medicine & medical imaging, 03 medical and health sciences, 0302 clinical medicine, In vivo, medicine, ultrasmall AGuIX nanoparticles, General Materials Science, PET/MR imaging, medicine.diagnostic_test, business.industry, Gallium-68, Magnetic resonance imaging, 021001 nanoscience & nanotechnology, medicine.disease, Radiation therapy, Positron emission tomography, [PHYS.PHYS.PHYS-MED-PH]Physics [physics]/Physics [physics]/Medical Physics [physics.med-ph], Dual modality, Radiology, 0210 nano-technology, Nuclear medicine, business, Ex vivo, Glioblastoma |
| الوصف: | Aim: The aim of this study was to develop a dual-modality positron emission tomography/magnetic resonance (PET/MR) imaging probe by radiolabeling gadolinium-containing AGuIX derivatives with the positron-emitter Gallium-68 (68Ga). Materials & methods: AGuIX@NODAGA nanoparticles were labeled with 68Ga at high efficiency. Tumor accumulation in an appropriate disease model was assessed by ex vivo biodistribution and in vivo PET/MR imaging. Results: 68Ga-AGuIX@NODAGA was proven to passively accumulate in U87MG human glioblastoma tumor xenografts. Metabolite assessment in serum, urine and tumor samples showed that 68Ga-AGuIX@NODAGA remains unmetabolized up to at least 60 min postinjection. Conclusion: This study demonstrates that 68Ga-AGuIX@NODAGA can be used as a dual-modality PET/MR imaging agent with passive accumulation in the diseased area, thus showing great potential for PET/MR image-guided radiation therapy. |
| تدمد: | 1748-6963 1743-5889 |
| DOI: | 10.2217/nnm-2017-0032 |
| DOI: | 10.2217/nnm-2017-0032⟩ |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::571847380ae0a794d348321b916fcf91 https://doi.org/10.2217/nnm-2017-0032 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....571847380ae0a794d348321b916fcf91 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17486963 17435889 |
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| DOI: | 10.2217/nnm-2017-0032 |