A ubiquitin ligase toggles red cell differentiation
| العنوان: | A ubiquitin ligase toggles red cell differentiation |
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| المؤلفون: | Thijs C. J. Verheul, Sjaak Philipsen |
| المساهمون: | Cell biology |
| المصدر: | Blood Blood, 137(2), 143-144. American Society of Hematology |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | 0301 basic medicine, Red Cell, Ubiquitin, Ubiquitin-Protein Ligases, Immunology, Regulator, Ubiquitination, Plenary Paper, Repressor, Cell Biology, Hematology, macromolecular substances, Biology, Biochemistry, Homology (biology), Ubiquitin ligase, Cell biology, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, Proteolysis, biology.protein, Erythropoiesis, Gene, 030215 immunology |
| الوصف: | The histone mark H3K27me3 and its reader/writer polycomb repressive complex 2 (PRC2) mediate widespread transcriptional repression in stem and progenitor cells. Mechanisms that regulate this activity are critical for hematopoietic development but are poorly understood. Here we show that the E3 ubiquitin ligase F-box only protein 11 (FBXO11) relieves PRC2-mediated repression during erythroid maturation by targeting its newly identified substrate bromo adjacent homology domain–containing 1 (BAHD1), an H3K27me3 reader that recruits transcriptional corepressors. Erythroblasts lacking FBXO11 are developmentally delayed, with reduced expression of maturation-associated genes, most of which harbor bivalent histone marks at their promoters. In FBXO11(−/−) erythroblasts, these gene promoters bind BAHD1 and fail to recruit the erythroid transcription factor GATA1. The BAHD1 complex interacts physically with PRC2, and depletion of either component restores FBXO11-deficient erythroid gene expression. Our studies identify BAHD1 as a novel effector of PRC2-mediated repression and reveal how a single E3 ubiquitin ligase eliminates PRC2 repression at many developmentally poised bivalent genes during erythropoiesis. |
| وصف الملف: | application/pdf |
| تدمد: | 1528-0020 0006-4971 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56daafcf6a3e2a4f1efe5d8c6299733f https://pubmed.ncbi.nlm.nih.gov/33156908 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....56daafcf6a3e2a4f1efe5d8c6299733f |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15280020 00064971 |
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