Association of Soluble Interleukin-2 Receptor and C-Reactive Protein with the Efficacy of Bendamustine Salvage Treatment for Indolent Lymphomas and Mantle Cell Lymphoma
| العنوان: | Association of Soluble Interleukin-2 Receptor and C-Reactive Protein with the Efficacy of Bendamustine Salvage Treatment for Indolent Lymphomas and Mantle Cell Lymphoma |
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| المؤلفون: | Yui Uto, Yuta Baba, So Murai, Norimichi Hattori, Megumi Watanuki, Nana Arai, Hiroyuki Tsukamoto, Maasa Abe, Kouji Yanagisawa, Nobuyuki Kabasawa, Hirotsugu Ariizumi, Hiroshi Harada, Shun Fujiwara, Bungo Saito, Tsuyoshi Nakamaki, Yukiko Kawaguchi |
| المصدر: | Acta Haematologica. 139:12-18 |
| بيانات النشر: | S. Karger AG, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | Adult, Male, Interleukin 2, Bendamustine, Lymphoma, Kaplan-Meier Estimate, Lymphoma, Mantle-Cell, 03 medical and health sciences, 0302 clinical medicine, Refractory, Bendamustine Hydrochloride, Humans, Medicine, Antineoplastic Agents, Alkylating, Aged, Neoplasm Staging, Aged, 80 and over, biology, business.industry, C-reactive protein, Receptors, Interleukin-2, Hematology, General Medicine, Middle Aged, medicine.disease, Pathophysiology, C-Reactive Protein, Treatment Outcome, 030220 oncology & carcinogenesis, biology.protein, Cancer research, Female, Mantle cell lymphoma, Rituximab, Neoplasm Grading, business, 030215 immunology, medicine.drug |
| الوصف: | Bendamustine has demonstrated favourable efficacy in relapsed or refractory indolent lymphoma and mantle cell lymphoma. We retrospectively evaluated the pre-treatment clinical and laboratory factors and their correlation with the clinical outcome of these lymphomas. We analysed 53 patients who had been treated with bendamustine alone (n = 6) or rituximab plus bendamustine (n = 47). The overall response rate was 81.1%, with a complete response (CR) rate of 39.6%. The CR rate was significantly low in patients who had elevated levels of soluble interleukin-2 receptor (p = 0.024) and C-reactive protein (CRP; p = 0.004). The 1-year overall survival (OS) rate was 79.3%. An elevated CRP was associated with a short OS (p = 0.056). The present findings suggest that the lymphoma microenvironment and immune response were involved in the effects of bendamustine. These findings are also important in order to understand the pathophysiology of refractory lymphoma and to find effective strategies using bendamustine. |
| تدمد: | 1421-9662 0001-5792 |
| DOI: | 10.1159/000484711 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5586a8d93b6cb407220de2e7d4ce6c73 https://doi.org/10.1159/000484711 |
| Rights: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....5586a8d93b6cb407220de2e7d4ce6c73 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14219662 00015792 |
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| DOI: | 10.1159/000484711 |