The role of perfusion effects in monitoring of chemoradiotherapy of rectal carcinoma using diffusion-weighted imaging
| العنوان: | The role of perfusion effects in monitoring of chemoradiotherapy of rectal carcinoma using diffusion-weighted imaging |
|---|---|
| المؤلفون: | Annette Kopp-Schneider, Maximilian Schuessler, Bram Stieltjes, Maria Katharina Ganten, M.W. Muenter, Heinz Peter Schlemmer, Tobias Bäuerle, Karsten Brand, Julien Dinkel, Klaus H. Fritzsche, Margret Dueck, Alexandra D Jensen |
| المصدر: | Cancer Imaging |
| بيانات النشر: | e-Med, 2013. |
| سنة النشر: | 2013 |
| مصطلحات موضوعية: | Adult, Male, medicine.medical_specialty, diffusion-weighted imaging, Text mining, Rectal carcinoma, medicine, Narrow range, Effective diffusion coefficient, Humans, Radiology, Nuclear Medicine and imaging, Intravoxel incoherent motion, Aged, Aged, 80 and over, tumor response, Radiological and Ultrasound Technology, business.industry, Rectal Neoplasms, General Medicine, Chemoradiotherapy, Middle Aged, Tumor Burden, monitoring, Diffusion Magnetic Resonance Imaging, Oncology, rectal carcinoma, Original Article, Female, Radiology, Intravoxel incoherent motion model, business, Perfusion, Diffusion MRI |
| الوصف: | Purpose: The aim of this study was to characterize and understand the therapy-induced changes in diffusion parameters in rectal carcinoma under chemoradiotherapy (CRT). The current literature shows conflicting results in this regard. We applied the intravoxel incoherent motion model, which allows for the differentiation between diffusion (D) and perfusion (f) effects, to further elucidate potential underlying causes for these divergent reports. Materials and methods: Eighteen patients with primary rectal carcinoma undergoing preoperative CRT were examined before, during, and after neoadjuvant CRT using diffusion-weighted imaging. Using the intravoxel incoherent motion approach, f and D were extracted and compared with postoperative tumor downstaging and volume. Results: Initial diffusion-derived parameters were within a narrow range (D1 = 0.94 ± 0.12 × 10−3 mm2/s). At follow-up, D rose significantly (D2 = 1.18 ± 0.13 × 10−3 mm2/s; P |
| اللغة: | English |
| تدمد: | 1470-7330 1740-5025 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::553a910b1d633eea67d07078036c84ae http://europepmc.org/articles/PMC3864228 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....553a910b1d633eea67d07078036c84ae |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14707330 17405025 |
|---|