Eosinophilic Granulomatosis with Polyangiitis: A Systematic Review and Meta‐Analysis of Test Accuracy and Benefits and Harms of Common Treatments
| العنوان: | Eosinophilic Granulomatosis with Polyangiitis: A Systematic Review and Meta‐Analysis of Test Accuracy and Benefits and Harms of Common Treatments |
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| المؤلفون: | Reem A. Mustafa, Kevin Byram, Mohamad A. Kalot, Mehrdad Maz, Anisha B. Dua, Sharon A. Chung, Carol A. Langford, Andy Abril, Yih Chang Lin, Nedaa Husainat, Marat Turgunbaev, Alexandra Villa-Forte, Karen E. James, Jason M. Springer |
| المصدر: | ACR Open Rheumatology, Vol 3, Iss 2, Pp 101-110 (2021) ACR Open Rheumatology |
| بيانات النشر: | Wiley, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | education.field_of_study, medicine.medical_specialty, lcsh:Diseases of the musculoskeletal system, Polyarteritis nodosa, business.industry, Population, Original Articles, medicine.disease, Dermatology, Rheumatology, medicine, Kawasaki disease, Original Article, lcsh:RC925-935, Vasculitis, Microscopic polyangiitis, Granulomatosis with polyangiitis, education, business, Anti-neutrophil cytoplasmic antibody, Systemic vasculitis |
| الوصف: | OBJECTIVE Eosinophilic granulomatosis with polyangiitis (EGPA) is part of a group of vasculitides commonly referred to as antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV), in addition to granulomatosis with polyangiitis (GPA), microscopic polyangiitis (MPA), and renal-limited vasculitis. Patients with EGPA characteristically have asthma and marked peripheral eosinophilia with only approximately 30% to 35% of patients being myeloperoxidase (MPO)-ANCA positive, distinguishing it from other forms of AAV (1,2). The aim of this systematic review is to support the development of the American College of Rheumatology/Vasculitis Foundation guideline for the management of EGPA. METHODS A systematic review was conducted of the literature for seven forms of primary systemic vasculitis (GPA, MPA, EGPA, polyarteritis nodosa, Kawasaki disease, giant cell arteritis, and Takayasu arteritis). The search was done for articles in English using Ovid Medline, PubMed, Embase, and the Cochrane Library. Articles were screened for suitability in addressing population/patients, intervention, comparator, and outcomes (PICO) questions, with studies presenting the highest level of evidence given preference. Two independent reviewers conducted a title/abstract screen and full-text review for each eligible study. RESULTS The initial search, conducted in August 2019, included 13 800 articles, of which 2596 full-text articles were reviewed. There were 190 articles (addressing 34 PICO questions) reporting on the diagnosis and management of EGPA. CONCLUSION This comprehensive systematic review synthesizes and evaluates the accuracy of commonly used tests for EGPA as well as benefits and toxicities of different treatment options. |
| اللغة: | English |
| تدمد: | 2578-5745 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5512e38a816962350e971dbd365ec31f https://doaj.org/article/072ddc8a2fa44410afc707bada78ae82 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....5512e38a816962350e971dbd365ec31f |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 25785745 |
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