The role of magnesium in different inflammatory diseases
| العنوان: | The role of magnesium in different inflammatory diseases |
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| المؤلفون: | Mohammad Reza Ataollahi, Saeed Aslani, Abbas Shahi, Mahdi Mahmoudi |
| المصدر: | Inflammopharmacology. 27:649-661 |
| بيانات النشر: | Springer Science and Business Media LLC, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | 0301 basic medicine, Immunology, Inflammation, medicine.disease_cause, Receptors, N-Methyl-D-Aspartate, Preeclampsia, Autoimmunity, 03 medical and health sciences, 0302 clinical medicine, Magnesium deficiency (medicine), Diabetes mellitus, medicine, Animals, Humans, Magnesium, Pharmacology (medical), Endothelial dysfunction, Pharmacology, business.industry, NF-kappa B, medicine.disease, Pathophysiology, 030104 developmental biology, Rheumatoid arthritis, medicine.symptom, business, Magnesium Deficiency, 030217 neurology & neurosurgery |
| الوصف: | Magnesium deficiency (MgD) can cause inflammation in human body. The known mechanisms of inflammation caused by MgD include activation of phagocytic cells, opening of calcium channels, activation of the N-methyl-D-aspartate (NMDA) receptor, and activation of nuclear factor (NF)-κB. In addition, MgD causes systemic stress response through neuroendocrinological pathways. The inflammation caused by MgD can result in pro-atherogenic changes in the metabolism of lipoproteins, endothelial dysfunction, and high blood pressure. Studies suggest that magnesium may play an important role in the pathophysiology of some inflammatory diseases. Several clinical trials and laboratory studies have been done on the functional role of magnesium. In this study, we review some inflammatory diseases, in which the magnesium has a role in their pathophysiology. Among these diseases, diabetes, asthma, preeclampsia, atherosclerosis, heart damage, and rheumatoid arthritis have been highlighted. |
| تدمد: | 1568-5608 0925-4692 |
| DOI: | 10.1007/s10787-019-00603-7 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::550a2b87040d611946da6d0405f57b9e https://doi.org/10.1007/s10787-019-00603-7 |
| Rights: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....550a2b87040d611946da6d0405f57b9e |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15685608 09254692 |
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| DOI: | 10.1007/s10787-019-00603-7 |