Cost-effectiveness of baloxavir marboxil compared with laninamivir for the treatment of influenza in patients at high risk for complications in Japan
| العنوان: | Cost-effectiveness of baloxavir marboxil compared with laninamivir for the treatment of influenza in patients at high risk for complications in Japan |
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| المؤلفون: | H. Ikeoka, Amir Ansaripour, Yoshie Onishi, Ataru Igarashi, Samuel Aballéa, Naoya Itsumura, Mariia Dronova, Nobuo Hirotsu, Mark Hill |
| المصدر: | Current Medical Research and Opinion. 37:1135-1148 |
| بيانات النشر: | Informa UK Limited, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Adult, Dibenzothiepins, medicine.medical_specialty, Adolescent, Pyridones, Cost effectiveness, Cost-Benefit Analysis, Morpholines, 030204 cardiovascular system & hematology, Antiviral Agents, Guanidines, 03 medical and health sciences, 0302 clinical medicine, Japan, Influenza, Human, medicine, Humans, In patient, 030212 general & internal medicine, Aged, Pyrans, Triazines, business.industry, General Medicine, Cost-effectiveness analysis, Middle Aged, biochemical phenomena, metabolism, and nutrition, Laninamivir, Emergency medicine, Sialic Acids, business |
| الوصف: | Baloxavir marboxil (baloxavir) is a single-dose antiviral which was previously found to be a cost-effective alternative to laninamivir in otherwise healthy adults in Japan. This study aimed at investigating the cost-effectiveness of baloxavir versus laninamivir in patients with influenza at high risk for complications.A decision tree was utilized to estimate costs and health gains associated with the use of antivirals. A lifetime horizon was applied to capture the long-term impact of influenza complications, and other events with associated costs and health outcomes were accounted for one influenza season. The study population was stratified into three categories: adolescents and non-elderly adults with high-risk conditions (HRC), elderly without other HRC, and elderly with other HRC. The cost-effectiveness was assessed from a public healthcare payer's perspective. The duration of influenza symptoms, probabilities of complications and probabilities of adverse events were obtained from a clinical trial and network meta-analysis. The costs of influenza and adverse events management were derived from the JammNet claims database. Utility values were informed by the clinical trial data and literature. Sensitivity analyses were also performed.The baloxavir strategy was associated with higher costs (+¥144) and higher quality-adjusted life-years (QALYs) in adults with HRC, elderly without HRC and elderly with HRC (+0.00078, +0.00183 and +0.00350 respectively). The overall incremental cost/QALY for baloxavir versus laninamivir was ¥68,855, which was below the willingness-to-pay threshold of ¥5 million/QALY gained. Key drivers of the model results were the probability of pneumonia and bronchitis. The probability of baloxavir being cost-effective was 72%.This study suggests that influenza treatment with baloxavir is cost-effective compared with laninamivir in the adult high-risk population in Japan. |
| تدمد: | 1473-4877 0300-7995 |
| DOI: | 10.1080/03007995.2021.1914942 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54e1ce6ac9fa8b04ad2435996892c929 https://doi.org/10.1080/03007995.2021.1914942 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....54e1ce6ac9fa8b04ad2435996892c929 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14734877 03007995 |
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| DOI: | 10.1080/03007995.2021.1914942 |